This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-huIgH296-SpCas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | SNCG |
| Insert Clone | BCGS-4206CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | 10-1000 |
| Charge (mv) | 10-90 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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