This product is a Toledo B cell engineering tool based on the Gold nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-289-tracr RNA-Cas9-L755507) genome editor.
| Host Cell | Toledo |
| Target | SNCG |
| Insert Clone | CBDH2850CR |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-150 |
| Charge (mv) | 10 to 35 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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