This product is a NCI-H929 [H929] B cell engineering tool based on the Solid lipid nanoparticles (Tumor-homing peptide tLyp-1/NRP-1) delivery system and CRISPR-based (SHS-227-huIgH296-SpCas9-SCR7 pyrazine) genome editor.
| Host Cell | NCI-H929 [H929] |
| Target | SNCG |
| Insert Clone | BCGS-0612CR |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-50 |
| Charge (mv) | <80 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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