This product is a MC/CAR B cell engineering tool based on the Magnetic nanoparticles (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (SHS-317-SpCas9-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | MC/CAR |
| Target | SPINT1 |
| Insert Clone | BCGS-5040CR |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Paclitaxel, chlorin e6 |
| Particle Size | <1660 |
| Charge (mv) | < 0 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Liver cancer |
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