This product is a CA46 B cell engineering tool based on the Microbubbles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (hROSA26-sgRNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | CA46 |
| Target | SPINT1 |
| Insert Clone | BCGS-5031CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Microbubbles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-150 |
| Charge (mv) | -10 to -35 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | VSV |
| Vector Name | BCpCDH7 |
| Targeting Diseases | Colorectal cancer; Breast cancer; Lung cancer; Liver cancer |
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