This product is a RPMI 8226 B cell engineering tool based on the Dendrimers (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-crispr RNA-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | RPMI 8226 |
| Target | αvβ5 Integrin |
| Insert Clone | BGB30 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Dendrimers |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | 22-500 |
| Charge (mv) | 11-91 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung cancer; Prostate cancer; Colorectal cancer |
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