This product is a Ramos (RA 1) B cell engineering tool based on the Liposomes (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | αvβ5 Integrin |
| Insert Clone | F-2IQ |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Liposomes |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Bortezomib |
| Particle Size | <3450 |
| Charge (mv) | 11-91 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Lung cancer; Prostate cancer; Colorectal cancer |
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