Methyltetrazine-NHS Ester Copper-Free Click Chemistry Reagent (CAT#: OLY-1023-YS228)

Description

This is a heterobifunctional linker for bioorthogonal 'Click Chemistry.' It contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a methyltetrazine moiety. The NHS ester is used to "install" the tetrazine handle onto a biomolecule (e.g., a protein or antibody) by reacting with its primary amines (lysines). The tetrazine group then participates in extremely fast, specific, and bioorthogonal Inverse-Electron-Demand Diels-Alder (IEDDA) "click" reactions with strained alkenes, such as trans-cyclooctene (TCO) or bicyclononyne (BCN), for cellular imaging or in vivo targeting.

Molecular Weight

327.30

Purity

>95.0%

Formula

C₁₅H₁₃N₅O₄

Product Type

Copper-Free Click Chemistry Reagents

Group 1

NHS

Group 2

Other

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, -20°C

Molecular Structure