Cas No.: 1415800-35-9
PRODUCT INFORMATION
Description
This heterobifunctional PEG linker features a thiol-reactive maleimide group and an acid-labile t-butyl (OtBu) ester, linked via a 4-unit PEG chain. The maleimide group is available for conjugation to sulfhydryl groups (cysteines). The t-butyl ester protects a terminal carboxylic acid. This protecting group is stable to the neutral-pH maleimide coupling but can be selectively removed using mild acid (e.g., TFA) to reveal the free carboxylic acid. This allows for a second, sequential coupling step (e.g., via EDC activation), making it useful for multi-step, orthogonal conjugation strategies.
Molecular Weight
472.54
Purity
>98.0%
Formula
C₂₂H₃₆N₂O₉
Product Type
Heterobifunctional Crosslinkers ; PEGylation Reagents
Group 1
Maleimide
Group 2
Other
Form (20 deg.C)
Liquid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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