Cas No.: 1585-90-6
PRODUCT INFORMATION
Description
This heterobifunctional crosslinker possesses a sulfhydryl-reactive maleimide group and a terminal primary hydroxyl group. The maleimide group reacts specifically with thiols (e.g., cysteine residues) at pH 6.5-7.5 to form a stable thioether bond. The terminal hydroxyl group is less nucleophilic than an amine but offers distinct conjugation possibilities. It is primarily used to prepare thiol-reactive surfaces by immobilizing the linker via its hydroxyl group, or to functionalize cysteine-containing molecules with a hydroxyl handle for further modification or enzymatic recognition (e.g., phosphorylation).
Molecular Weight
141.13
Purity
>98.0%
Formula
C₆H₇NO₃
Product Type
Heterobifunctional Crosslinkers
Group 1
Maleimide
Group 2
OH
Form (20 deg.C)
Solid
Storage Condition
-20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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