Fmoc-8-amino-3,6-dioxaoctanoic Acid PEGylation Crosslinker (CAT#: OLY-1023-YS45)

Description

This linker, also known as Fmoc-AEEA or Fmoc-PEG2-acid, is a common heterobifunctional building block used in solid-phase peptide synthesis (SPPS). It features a base-labile Fmoc-protected amine and a terminal carboxylic acid, separated by a short, hydrophilic 2-unit PEG spacer (AEEA). In SPPS, the carboxylic acid is coupled to the N-terminus of a growing peptide chain. The Fmoc group is then removed with mild base (e.g., piperidine) to reveal a new primary amine, allowing for peptide chain elongation or branching.

Molecular Weight

385.42

Purity

>97.0%

Formula

C₂₁H₂₃NO₆

Product Type

Heterobifunctional Crosslinkers ; PEGylation Reagents

Group 1

COOH

Group 2

Other

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, -20°C

Molecular Structure