Cas No.: 42014-51-7
PRODUCT INFORMATION
Description
This heterobifunctional crosslinker contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive bromoacetyl group. The NHS ester reacts with primary amines (lysines) at pH 7.0-9.0. The bromoacetyl group is a thiol-specific alkylating agent, reacting at pH 7.5-8.5 to form a highly stable, non-cleavable thioether bond. Compared to a maleimide, the bromoacetyl group is more stable to hydrolysis but generally reacts more slowly. It is used for short-range, stable crosslinking of amines to thiols.
Molecular Weight
236.02
Purity
>98.0%
Formula
C₆H₆BrNO₄
Product Type
Heterobifunctional Crosslinkers
Group 1
X (F, Cl, Br, I)
Group 2
NHS
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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