N-Succinimidyl Bromoacetate Heterobifunctional Crosslinker (CAT#: OLY-1023-YS28)

Description

This heterobifunctional crosslinker contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive bromoacetyl group. The NHS ester reacts with primary amines (lysines) at pH 7.0-9.0. The bromoacetyl group is a thiol-specific alkylating agent, reacting at pH 7.5-8.5 to form a highly stable, non-cleavable thioether bond. Compared to a maleimide, the bromoacetyl group is more stable to hydrolysis but generally reacts more slowly. It is used for short-range, stable crosslinking of amines to thiols.

Molecular Weight

236.02

Purity

>98.0%

Formula

C₆H₆BrNO₄

Product Type

Heterobifunctional Crosslinkers

Group 1

X (F, Cl, Br, I)

Group 2

NHS

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, <0°C

Molecular Structure