Cas No.: 42014-51-7
PRODUCT INFORMATION
Description
This heterobifunctional crosslinker contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive bromoacetyl group. The NHS ester reacts with primary amines (lysines) at pH 7.0-9.0. The bromoacetyl group is a thiol-specific alkylating agent, reacting at pH 7.5-8.5 to form a highly stable, non-cleavable thioether bond. Compared to a maleimide, the bromoacetyl group is more stable to hydrolysis but generally reacts more slowly. It is used for short-range, stable crosslinking of amines to thiols.
Molecular Weight
236.02
Purity
>98.0%
Formula
C₆H₆BrNO₄
Product Type
Heterobifunctional Crosslinkers
Group 1
X (F, Cl, Br, I)
Group 2
NHS
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- N-(2-Hydroxyethyl)maleimide Heterobifunctional Crosslinker (CAT#: OLY-1023-YS7)
- N,N'-Disuccinimidyl Carbonate (CAT#: OLY-1023-YS131)
- Biotin-PEG2-amine Biotins Conjugation Reagent (CAT#: OLY-1023-YS200)
- m-PEG24-maleimide PEGylation Crosslinker (CAT#: OLY-1023-YS246)
- β-Alanine tert-butyl Ester Hydrochloride Heterobifunctional Crosslinker (CAT#: OLY-1023-YS112)
- m-PEG4-amine PEGylation Crosslinker (CAT#: OLY-1023-YS234)
- 4-N3Pfp-NHS Ester (CAT#: OLY-1023-YS54)
- PEG Dithiol 2000 (CAT#: OLY-1023-YS261)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.