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CA125 Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H200 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CA125 Human HER2 Human Inquiry
T-BSDB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CA125 Mouse HER2 Mouse Inquiry
SCIGG-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scIgG) Human Single chain IgGs CA125 Human HER2 Human Inquiry
SCIGG-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scIgG) Human Single chain IgGs CA125 Mouse HER2 Mouse Inquiry
FVTIG-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CA125 Human HER2 Human Inquiry
FVTIG-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CA125 Mouse HER2 Mouse Inquiry
BSSG-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scFv-IgG) Human scFv-IgG CA125 Human HER2 Human Inquiry
BSSG-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scFv-IgG) Human scFv-IgG CA125 Mouse HER2 Mouse Inquiry
IGLFV-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CA125 Human HER2 Human Inquiry
IGLFV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CA125 Mouse HER2 Mouse Inquiry
BSGV-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (IgG-Fv) Human IgG-Fv CA125 Mouse HER2 Mouse Inquiry
BSGV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG-Fv) Human IgG-Fv CA125 Mouse HER2 Mouse Inquiry
BSDG-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Fv-IgG) Human Fv-IgG CA125 Human HER2 Human Inquiry
BSDG-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fv-IgG) Human Fv-IgG CA125 Mouse HER2 Mouse Inquiry
BABFV-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CA125 Human HER2 Human Inquiry
BABFV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CA125 Mouse HER2 Mouse Inquiry
FABVC-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CA125 Human HER2 Human Inquiry
FABVC-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CA125 Mouse HER2 Mouse Inquiry
SCDBC-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CA125 Human HER2 Human Inquiry
SCDBC-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CA125 Mouse HER2 Mouse Inquiry
BSDBC-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CA125 Human HER2 Human Inquiry
BSDBC-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CA125 Mouse HER2 Mouse Inquiry
SCDBF-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CA125 Human HER2 Human Inquiry
SCDBF-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CA125 Mouse HER2 Mouse Inquiry
BSFVF-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CA125 Human HER2 Human Inquiry
BSFVF-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CA125 Mouse HER2 Mouse Inquiry
BSDBF-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CA125 Human HER2 Human Inquiry
BSDBF-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CA125 Mouse HER2 Mouse Inquiry
BSTF-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CA125 Mouse HER2 Mouse Inquiry
BSTF-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CA125 Mouse HER2 Mouse Inquiry
BSCFV-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc CA125 Mouse HER2 Mouse Inquiry
BSCFV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scFv-Fc) Human scFv-Fc CA125 Mouse HER2 Mouse Inquiry
MNAB-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Miniantibody) Human Miniantibody CA125 Mouse HER2 Mouse Inquiry
MNAB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Miniantibody) Human Miniantibody CA125 Mouse HER2 Mouse Inquiry
BSFC-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CA125 Mouse HER2 Mouse Inquiry
BSFC-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CA125 Mouse HER2 Mouse Inquiry
BSCC-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CA125 Mouse HER2 Mouse Inquiry
BSCC-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CA125 Mouse HER2 Mouse Inquiry
BIBD-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Bibody) Human Bibody CA125 Mouse HER2 Mouse Inquiry
BIBD-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Bibody) Human Bibody CA125 Mouse HER2 Mouse Inquiry
FABFV-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Fab-Fv) Human Fab-Fv CA125 Human HER2 Human Inquiry
FABFV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-Fv) Human Fab-Fv CA125 Mouse HER2 Mouse Inquiry
MiniB-H202 Recombinant Human Anti-CA125 x Human Anti-HER2 Bispecific Antibody (Minibody) Human Minibody CA125 Human HER2 Human Inquiry
MiniB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Minibody) Human Minibody CA125 Mouse HER2 Mouse Inquiry
SCDB-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CA125 Human HER2 Human Inquiry
FABIG-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CA125 Human HER2 Human Inquiry
TRIB-H202 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CA125 Human HER2 Human Inquiry
BSIG-H200 Human Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CA125 Human HER2 Human Inquiry
CROSSAB-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CA125 Human HER2 Human Inquiry
IGFV-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG-scFv) Human IgG-scFv CA125 Human HER2 Human Inquiry
BSDB-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CA125 Human HER2 Human Inquiry
BSFAB-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem Fab) Human Tandem Fab CA125 Human HER2 Human Inquiry
BSFV-H200 Recombinant Human Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CA125 Human HER2 Human Inquiry
FABIG-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-IgG) Human Fab-IgG CA125 Mouse HER2 Mouse Inquiry
TRIB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CA125 Mouse HER2 Mouse Inquiry
BSIG-025 Anti-CA125 x Anti-HER2 Bispecific Antibody (IgG-IgG) Human IgG-IgG CA125 Mouse HER2 Mouse Inquiry
CROSSAB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (CrossMab) Human CrossMab CA125 Mouse HER2 Mouse Inquiry
BSDB-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Diabody) Human Diabody CA125 Mouse HER2 Mouse Inquiry
BSFV-025 Recombinant Anti-CA125 x Anti-HER2 Bispecific Antibody (Tandem scFv) Human Tandem scFv CA125 Mouse HER2 Mouse Inquiry

Background

Cancer Antigen 125 (CA125) assumes the distinction of being the most renowned biomarker for epithelial ovarian cancer, having played a pivotal role in the screening and differential diagnosis of pelvic masses over the past decades. The efficacy of its tandem measurement with HE4 has been significantly corroborated.

CA125 presents itself as a high molecular weight mucin glycoprotein expressed on the surface of ovarian cancer cells. Quantification of CA125 shed into patient serum samples is exploited in the prognostication of ovarian cancer at stages I and II.

Further analysis reveals CA125 as an epitope on the molecule MUC16, a glycoprotein of approximately 2.5MDa, which has ascended to be recognized as one of the three most frequently mutated genes in a plethora of cancer types. The interactions of MUC16 with its ligands inhibit NK cell-mediated tumor cell destruction and cell recognition, thereby fostering the survival of tumor cells.

CA125 and ovarian cancer. (Charkhchi, et al., 2020) Fig.1 CA125 and ovarian cancer.1

Reference

  1. Charkhchi, Cybulski, et al. " CA125 and Ovarian Cancer: A Comprehensive Review." Cancer. 12 (2020): 3730.
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