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PLAP Bispecific Antibodies
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Product List

CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H273 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Human PLAP Human Inquiry
T-BSDB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD3 Mouse PLAP Mouse Inquiry
SCIGG-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Human PLAP Human Inquiry
SCIGG-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scIgG) Human Single chain IgGs CD3 Mouse PLAP Mouse Inquiry
FVTIG-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Human PLAP Human Inquiry
FVTIG-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD3 Mouse PLAP Mouse Inquiry
BSSG-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Human PLAP Human Inquiry
BSSG-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scFv-IgG) Human scFv-IgG CD3 Mouse PLAP Mouse Inquiry
IGLFV-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Human PLAP Human Inquiry
IGLFV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD3 Mouse PLAP Mouse Inquiry
BSGV-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse PLAP Mouse Inquiry
BSGV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (IgG-Fv) Human IgG-Fv CD3 Mouse PLAP Mouse Inquiry
BSDG-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Human PLAP Human Inquiry
BSDG-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Fv-IgG) Human Fv-IgG CD3 Mouse PLAP Mouse Inquiry
BABFV-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Human PLAP Human Inquiry
BABFV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD3 Mouse PLAP Mouse Inquiry
FABVC-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Human PLAP Human Inquiry
FABVC-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD3 Mouse PLAP Mouse Inquiry
SCDBC-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Human PLAP Human Inquiry
SCDBC-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD3 Mouse PLAP Mouse Inquiry
BSDBC-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Human PLAP Human Inquiry
BSDBC-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD3 Mouse PLAP Mouse Inquiry
SCDBF-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Human PLAP Human Inquiry
SCDBF-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD3 Mouse PLAP Mouse Inquiry
BSFVF-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Human PLAP Human Inquiry
BSFVF-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD3 Mouse PLAP Mouse Inquiry
BSDBF-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Human PLAP Human Inquiry
BSDBF-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD3 Mouse PLAP Mouse Inquiry
BSTF-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse PLAP Mouse Inquiry
BSTF-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD3 Mouse PLAP Mouse Inquiry
BSCFV-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse PLAP Mouse Inquiry
BSCFV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse PLAP Mouse Inquiry
MNAB-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse PLAP Mouse Inquiry
MNAB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse PLAP Mouse Inquiry
BSFC-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse PLAP Mouse Inquiry
BSFC-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse PLAP Mouse Inquiry
BSCC-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse PLAP Mouse Inquiry
BSCC-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse PLAP Mouse Inquiry
BIBD-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Bibody) Human Bibody CD3 Mouse PLAP Mouse Inquiry
BIBD-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Bibody) Human Bibody CD3 Mouse PLAP Mouse Inquiry
FABFV-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human PLAP Human Inquiry
FABFV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse PLAP Mouse Inquiry
MiniB-H275 Recombinant Human Anti-CD3 x Human Anti-PLAP Bispecific Antibody (Minibody) Human Minibody CD3 Human PLAP Human Inquiry
MiniB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Minibody) Human Minibody CD3 Mouse PLAP Mouse Inquiry
SCTB-H168 Recombinant Human Anti-PLAP x Human Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Human PLAP Human Inquiry
SCDB-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Human PLAP Human Inquiry
FABIG-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Human PLAP Human Inquiry
TRIB-H275 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Human PLAP Human Inquiry
BSIG-H273 Human Anti-CD3 x Anti-PLAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Human PLAP Human Inquiry
CROSSAB-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (CrossMab) Human CrossMab CD3 Human PLAP Human Inquiry
IGFV-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Human PLAP Human Inquiry
BSDB-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (Diabody) Human Diabody CD3 Human PLAP Human Inquiry
BSFAB-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Human PLAP Human Inquiry
BSFV-H273 Recombinant Human Anti-CD3 x Anti-PLAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Human PLAP Human Inquiry
SCTB-072 Recombinant Anti-PLAP x Anti-CD3 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD3 Mouse PLAP Mouse Inquiry
SCDB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD3 Mouse PLAP Mouse Inquiry
FABIG-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Fab-IgG) Human Fab-IgG CD3 Mouse PLAP Mouse Inquiry
TRIB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD3 Mouse PLAP Mouse Inquiry
BSIG-099 Anti-CD3 x Anti-PLAP Bispecific Antibody (IgG-IgG) Human IgG-IgG CD3 Mouse PLAP Mouse Inquiry
CROSSAB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (CrossMab) Human CrossMab CD3 Mouse PLAP Mouse Inquiry
IGFV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (IgG-scFv) Human IgG-scFv CD3 Mouse PLAP Mouse Inquiry
BSDB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Diabody) Human Diabody CD3 Mouse PLAP Mouse Inquiry
BSFAB-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Tandem Fab) Human Tandem Fab CD3 Mouse PLAP Mouse Inquiry
BSFV-099 Recombinant Anti-CD3 x Anti-PLAP Bispecific Antibody (Tandem scFv) Human Tandem scFv CD3 Mouse PLAP Mouse Inquiry

Background

Placental alkaline phosphatase (PLAP), also known as ALPP, is a metalloenzyme with a homodimeric functional structure, catalyzing the hydrolysis of phosphoric acid monoesters. This member of the alkaline phosphatase multigene family, comprising four isoenzymes, is predominantly located in the liver, endometrial tissue of pregnant women, and the placenta. Recent investigations reveal the expression of placental-type alkaline phosphatase on the surface of certain tumor cells, presenting a therapeutic avenue constrained by heterogeneous tumor expression. In the context of lung adenocarcinoma models, the use of EGFR inhibitors emerges as a strategy to augment ALPP surface expression. These findings substantiate the potential efficacy of a novel combination treatment modality involving ALPP-ADC directed therapy.

Proposed schematic: EGFR inhibition-induced surface upregulation of ALPP/PLAP in cancer cells. (Chen, et al., 2023) Fig.1 Proposed schematic: EGFR inhibition-induced surface upregulation of ALPP/PLAP in cancer cells.1

Reference

  1. Chen, Yihui, et al. "EGFR inhibition in lung adenocarcinoma upregulates cell surface expression of the placental antigen ALPP and enhances efficacy of ALPP-ADC therapy." bioRxiv (2023): 2023-03.
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