Introduction of CACNA1I
CACNA1I, calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3, is a protein which in humans is encoded by the CACNA1I gene. This kind of voltage-sensitive calcium channel mediates the calcium influx into excitable cells and is also involved in a variety of calcium-dependent processes, such as muscle contraction, neurotransmitter release or hormone, gene expression, cell division, motility, and death. A special characteristic of this type of channels is an opening at quite negative potentials.
|Basic Information of CACNA1I|
|Protein Name||Voltage-dependent T-type calcium channel subunit alpha-1I|
|Aliases||Voltage-gated calcium channel subunit alpha Cav3.3, Cav3.3, KIAA1120|
|Organism||Homo sapiens (Human)|
Function ofCACNA1I Membrane Protein
CACNA1I is also called Cav3.3. Mediating the calcium influx into excitable cells, this kind of voltage-sensitive calcium channel is also involved in a variety of calcium-dependent processes, such as muscle contraction, neurotransmitter release or hormone, gene expression, cell division, motility, and death. A special characteristic of this type of channels is an opening at quite negative potentials. It belongs to the "low-voltage activated" group and can be strongly blocked by mibefradil and nickel. In addition, it serves pacemaking functions in both central neurons and cardiac nodal cells and supports calcium signaling in secretory cells and vascular smooth muscle. It also may be involved in the modulation of firing patterns of neurons which is vital for information processing and in cell growth processes.
Fig.1 Calcium channel α1 subunit. (Huang, 2017)
Application of CACNA1I Membrane Protein in Literature
This article indicates that mutagenesis in the Cav3.3 channel has a partial contribution of the S4-S5 linker of Domain II to LVA behavior, with synergic effects observed in double and triple mutations. These findings demonstrate that IIS4 and, IVS4, voltage sensors are important in determining the LVA properties of Cav3.3 channels, although the accomplishment of this function relies on the participation of other structural elements such as S4-S5 linkers.
This article indicates that CACNA1I is a risk gene for schizophrenia in Chinese population. This gene provides further evidence which supports the role of neuronal calcium signaling in SCZ.
This study reveals the evidence that important association exists between the CACNA1I gene and schizophrenia in the Uighur Chinese population. Then the study provides functional analysis and genetic association studies to extend this research.
This article demonstrates that Cav3.3 calcium channel is regulated by intracellular calcium through interaction between Calcium/Calmodulin with the carboxyl terminus of Cav3.3.
This article reveals a novel mechanism of neuritin in synaptic transmission in the medial prefrontal cortex, which is by increasing Cav3.3 surface expression. This study indicates the IR and ERK signaling pathway is involved in this mechanism.
CACNA1I Preparation Options
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