CACNG7 Membrane Protein Introduction

Introduction of CACNG7

The voltage-dependent calcium channel gamma-7 subunit (CACNG7) is an integral membrane protein encoded by gene CACNG7. The calcium channel gamma subunits comprise an eight-member protein family. Just like CACNG6, CACNG7 is also a member of voltage-dependent calcium channel gamma subunits and usually has a role in stabilizing calcium channels. But its functions are more diverse and more important.

Basic Information of CACNG7
Protein Name	Voltage-dependent calcium channel gamma-7 subunit
Gene Name	CACNG7
Aliases	Neuronal voltage-gated calcium channel gamma-7 subunit, TARP gamma-7, Transmembrane AMPAR regulatory protein gamma-7
Organism	Homo sapiens (Human)
UniProt ID	P62955
Transmembrane Times	4
Length (aa)	275
Sequence	MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWRVCFFAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATPFPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNRPSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC

Function of CACNG7 Membrane Protein

CACNG7 is a subunit of the calcium channel gamma subunits, and the calcium channel gamma subunits are part of voltage-gated L-type calcium channels (VLCCs). VLCCs are a group of voltage-gated ion channels found in the membrane of excitable cells. Firstly, CACNG7 can regulate the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Secondly, CACNG7 can modulate the transport and gating properties of the AMPA-selective glutamate receptor (AMPAR) by slowing down their activation, inactivation and desensitization rates and by modulating their resensitization to promote their targeting to cell membranes and synapses. Thirdly, it can show subunit-specific AMPA receptor regulation.

Fig.1 CACNG7 is involved in skeletal muscle development (Amy, 2017)

Application of CACNG7 Membrane Protein in Literature

Gronich N., et al. Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy. Channels (Austin). 2010, 4(2): 101-107, PubMed ID: 20090424

This article reports that CACNG7 is decreased in atrial and ventricular myocytes of patients with ischemic cardiomyopathy and induces FXYD1 overexpression, which is a key gene for maintaining Na⁺ and K⁺ homeostasis.
Moss F.J., et al. The novel product of a five-exon stargazin-related gene abolishes CaV2.2 calcium channel expression. EMBO J. 2002, 21(7): 1514-1523. PubMed ID: 11927536

This article reveals that CACNG7 is a five-exon gene encoding a γ7 protein that is almost eliminated by the CaV2.2 channel when it is transiently co-expressed with γ7 in Xenopus oocytes or COS-7 cells.

CACNG7 Preparation Options

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Reference

Amy E Brinegar, et al. (2017). Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions. eLife.

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