Aptamer-guided Combination Solution

Aptamers are being intensively investigated as specific targeting moieties in the biological area. Creative Biolabs provides a broad range of unique aptamer-based combination strategies to maximize the use of aptamers and current advanced technology to achieve the best diagnostic or therapeutic outcomes for academic research trials.

Aptamer-guided Active Targeting

The goal of surface modification of drug carriers by aptamers is to enhance internalization, specific drug accumulation, and retention in tumors via specific ligand-mediated interactions, therefore, increasing the therapeutic index. Aptamer-guided active targeting enables the increased delivery of therapeutic agents to tumors as well as a reduction in toxicity and side effects by minimizing the exposure of normal tissues to the therapeutic agent. As an active targeting ligand, aptamers are generally non-immunogenic or low-immunogenic. In brief, aptamer-mediated active targeting for cancer therapy can be categorized into four groups:

• Free aptamer (DNA/RNA) as molecularly targeted agents
• Aptamer-drug conjugates
• Aptamer-nanoparticle-drug delivery system
• Aptamer-mediated cancer nucleic acid therapy

Fig.1 General scheme of drug delivery to tumor. (Xiang, 2015)

Our Aptamer-based Combination Strategies

Aptamers are short chemically synthesized oligonucleotides that can be further chemically modified to acquire desirable attributes for clinical applications. A wide range of diagnostic agents, therapeutic agents, and imaging agents can be used in combination with aptamers, via chemical or physical conjugation. For instance, aptamer-linked biosensors can be detected using various techniques such as fluorescence, chemiluminescence, electrochemistry, or immunoluminescence. This combination has been used for accurate and rapid detection of disease biomarkers, pathogens, antibiotics, toxins, pollutes, and other biomolecules or chemicals. Besides, non-invasive imaging of various disease markers using aptamer-modified probes has shown numerous advantages over traditional imaging techniques.

Advantages

• Provide synergistic or addictive effects beyond one single drug therapy
• Circumvent multiple drug resistance of cancer cells by targeted delivery of anticancer agents intracellularly
• Afford lower doses of individual drugs thus minimizing systematic side effects of individual agents

Combinational Solutions

• Aptamer-DNA combination
• Aptamer-miRNA combination
• Aptamer-shRNA combination
• Aptamer-siRNA chimera

Generating a chimera by linking an aptamer with siRNA, aptamer-guided siRNA delivery via receptor-mediated endocytosis serves as a promising approach for cancer-targeted RNAi therapy.

• Aptamer-drug combination
• Aptamer-biosensor combination
• Aptamer-boimaging combination

For detailed pricing information, please contact us for a custom quotation.

Reference

1. Xiang, D.; et al. Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine. Theranostics. 2015, 5(1): 23.

For Research Use Only.