Electrochemical biosensors have aroused burgeoning attention because of its intrinsic strengths such as cost-effectivity, flexibility, miniaturized instrumentation, and excellent sensitivity. Virus has a very simple structure consisting of genetic material in the form of DNA or RNA within a protein capsule. Electrochemical biosensors provide different strategies for virus detection. With years of experience, Creative Biolabs provides electrochemical biosensor development services, aiming to offer efficient virus detection tools for customers around the world.
During last few decades, virus borne infectious diseases causing outbreaks and become the major concern of today's world which includes influenza virus, human immune deficiency virus (HIV), Ebola virus (EBV), Zika virus (ZIKV), dengue virus (DENV), hepatitis virus and most recently COVID-19. Up to now, many techniques have been developed to identify virus. The conventional methods for detecting viruses are expensive, time-consuming, often poor reproducible, and specialist facilities/trained personnel dependent. These methods can be categorized as Figure 1 shown. Recent years, electrochemical biosensors have emerged as reliable analytical devices and represent a new promising tool for the detection of different pathogenic viruses.
Fig.1 Virus detection approaches.
Electrochemical biosensors are the biosensing devices containing electrochemical transducer that transforms biochemical information. It usually depends on the enzymatic catalysis reaction between the immobilized biomolecules and the targeted analyte that produces electrons and affects the electrical properties of the solution. Among the various kinds of biosensors, the following three types are primarily focused.
Fig.2 Potential electrochemical biosensor platforms for the detection of various pathogenic viruses. (Khan, 2020)
For instance, hepatitis B virus (HBV) can be detected with electrochemical biosensors. People who are exposed to the virus will accordingly show normally IgG antibodies against hepatitis B surface antigen. These antibodies can be used as a recognition element. An electrochemical biosensor based on a sandwich immunoassay was used for rapid detection of anti-hepatitis B virus antibodies in human serum. Magnetic beads were utilized as bioreaction platforms and Au nanoparticles (AuNPs) were used as electroactive labels.
Fig.3 Schematic diagram of HBV detection by electrochemical biosensors. (Huang, 2017)
Depending on the biological element incorporated, different types of electrochemical biosensors could be constructed. If you are looking for electrochemical biosensor for virus detection, please feel free to contact us for more information.
References
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