Creative Biolabs works as an outstanding expert in the antibody development field. We have established a proprietary and robust in vitro diagnostic (IVD) platform that enables us to provide first-class IVD antibody development services to our global clients, thereby facilitating and speeding their path to the development of antibody-based diagnostic immunoassays. Here, we introduce our IVD antibody development services for the fetuin-A marker.

Fetuin-A

Fetuin-A, also known as 2-Heremans Schmid glycoprotein (AHSG), is a 59 KD circulating glycoprotein that consists of two amino-terminal cystatin domains and a smaller carboxyl-terminal domain, synthesized constantly in the liver. It distributes most in the bone tissue, then in blood and cerebrospinal fluid. Fetuin-A is major calcification inhibitor, which interferes with calcium salt precipitation. Besides, it is one of the negative acute phase proteins in the inflammatory response. It induces toller-like receptors around type 2 diabetic patients, then may cause insulin resistance, which is an important step in the development of the type 2 diabetes mellitus. In addition, fetuin-A plays an important role in diverse normal and pathological processes, including regulation of bone metabolism, control protease activity, keratinocytes migration, and breast tumor cell proliferative signaling.

Cartoon of human fetuin-A/α2-HS glycoprotein. Fig.1 Cartoon of human fetuin-A/α2-HS glycoprotein. (Jahnen-Dechent W., 2011)

Fetuin-A Marker of Acute Kidney Injury (AKI)

Since fetuin-A is the most powerful inhibitor of ectopic calcification in vivo, it participates in the active calcification process of multiple factors regulation in the body. Studies have been shown that the deficiency of fetuin-A the calcification proneness of lung, heart, and kidneys in mice even without a mineral-rich diet or surgical tissue trauma. At first, fetuin-A was found to be an inhibitor of vascular calcification and involves the progression of vascular sclerosis and cardiovascular disease. Besides, fetuin-A was also identified to possess anti-inflammatory properties and functions as a negative acute-phase reactant in sepsis and endotoxemia. Decreased serum fetuin-A concentration is associated with a higher mortality rate in dialysis patients. Fetuin-A can act as a predictor for mortality of chronic kidney diseases. Furthermore, the fetuin-A levels are also associated with the progress of AKI and the urinary exosomal fetuin-A is increased in AKI. Thus fetuin-A also can be considered as a potential marker for detecting acute kidney injury.

Mechanisms depicted here are some of those involved in vascular calcification in chronic kidney disease.Fig. 2 Mechanisms depicted here are some of those involved in vascular calcification in chronic kidney disease. (Schiffrin E L., 2007)

IVD Antibody Development Services Targeting Fetuin-A Marker

Aided by our advanced IVD platform, Creative Biolabs is able to generate antibodies with high affinity and specificity that are specific to diagnostic targets, such as fetuin-A marker. Besides, we also provide services to biotech companies and academic researchers for their needs in developing diagnostic immunoassays of various formats, including lateral flow assay, ELISA, latex-based assays, etc. With the successful completion of numerous projects, Creative Biolabs is confident in providing services and products of the best quality.

If you are interested in the services we provide, please don't hesitate to contact us or directly send us an inquiry. We will get in touch with you as soon as possible.

References

  1. Jahnen-Dechent W., (2011). “Fetuin-A regulation of calcified matrix metabolism”. Circulation Research, 108(12): 1494-1509.
  2. Schiffrin E L., (2007). “Chronic Kidney Disease Effects on the Cardiovascular System”. Circulation, 116(1): 85-97.

For lab research use only.



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