As a leading CRO of antibody generation and development, Creative Biolabs offers application-specific antibody development services to global clients. With experienced scientists and advanced technology, we have established a series of high-quality in vitro diagnostic (IVD) antibody development services against biomarkers of different diseases. Here, we introduce our IVD antibody development services for IL-6 marker.
Interleukin 6 (IL-6)
Interleukin 6 (IL-6) is a protein that in humans is encoded by the IL6 gene. It acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.
- Interleukin 6 is secreted by T cells and macrophages to stimulate an immune response.
- Osteoblasts secrete IL-6 to stimulate osteoclast formation.
- Smooth muscle cells in the tunica media of many blood vessels produce IL-6 as a pro-inflammatory cytokine.
- IL-6 is an important mediator of fever and of the acute phase response. It is capable of crossing the blood-brain barrier and initiating synthesis of PGE2 in the hypothalamus, thereby changing the body's temperature setpoint. In muscle and fatty tissue, IL-6 stimulates energy mobilization that leads to increased body temperature.
- IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow.
Fig.1 The structure of IL-6.1
IL-6 Marker of Liver Failure
IL-6 has long been recognized as an important proinflammatory cytokine whose expression is associated with many inflammatory disorders. Serum levels of IL-6 increase rapidly after infection or organ inflammation and are therefore used in clinical practice as a diagnostic marker to detect inflammatory conditions. levels of IL-6 are also strongly elevated in patients with acute and chronic liver diseases.
IL-6 plays an important role in liver regeneration and protection against liver damage. In addition to IL-6 classic signaling via membrane-bound receptor (mIL-6R), IL-6 signaling can also be mediated by soluble IL-6R (sIL-6R) thereby activating cells that do not express membrane-bound IL-6R.
The role of IL-6 dependent signaling in the liver was mainly attributed to induction of the acute phase response. The functional relevance of IL-6 dependent signaling for regulation of different physiological and pathophysiological conditions in the liver was confirmed in other animal models.
In patients with fulminant hepatic failure or chronic liver diseases, IL-6 expression in serum and liver tissue correlates with disease progression. In contrast to its pathogenic role in liver cancer, IL-6 has been associated with protective functions during hepatic fibrogenesis.
IVD Antibody Development Services for IL-6 Marker
In recent years, IVD technologies are undergoing rapid development. IVD antibodies have been widely used in the diagnosis of numerous diseases. Antibody-based immunoassays are the most generally used diagnostic assays for the detection of biomolecules. With advanced technology and professional scientists, Creative Biolabs is capable of offering a full range of IVD antibody development services against various markers for global customers. In addition, Creative Biolabs provides one-stop diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, validation, and production.
For more information, please feel free to contact us and get a quote.
Reference
- From Wiki: By Ramin Herati - Created from PDB 1ALU and rendered by me using Pymol https://commons.wikimedia.org/wiki/File:IL6_Crystal_Structure.rsh.png
For Research Use Only.
