As a leading CRO of antibody generation and development, Creative Biolabs offers application-specific antibody development services to global clients. With experienced scientists and advanced technology, we have established a series of high-quality in vitro diagnostic (IVD) antibody development services against biomarkers of different diseases. Here, we introduce our IVD antibody development services for IL-6 marker.

Interleukin 6 (IL-6)

Interleukin 6 (IL-6) is a protein that in humans is encoded by the IL6 gene. It acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.

  • Interleukin 6 is secreted by T cells and macrophages to stimulate an immune response.
  • Osteoblasts secrete IL-6 to stimulate osteoclast formation.
  • Smooth muscle cells in the tunica media of many blood vessels produce IL-6 as a pro-inflammatory cytokine.
  • IL-6 is an important mediator of fever and of the acute phase response. It is capable of crossing the blood-brain barrier and initiating synthesis of PGE2 in the hypothalamus, thereby changing the body's temperature setpoint. In muscle and fatty tissue, IL-6 stimulates energy mobilization that leads to increased body temperature.
  • IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow.

(A) Selected members of the IL-6 cytokine family and their receptors (schematic). (B) IL-6 binds to IL-6R/gp80, eg, on hepatocytes. IL-6-gp80 then complexes with the signal-transducing molecule gp130. The complex of IL-6, gp80 (IL-6R), and two gp130 molecules mediates IL-6 signaling via phosphorylation of tyrosine (Y) residues of the intracellular gp130 molecule. Depending on the location of the phosphorylated tyrosines, STAT proteins (mainly STAT3), and also the Ras/MAPK pathway become activated and trigger the downstream effects. Abbreviation: R, receptor. Fig.1 The IL-6 cytokine family and IL6 signaling in the liver. (Hammerich, L., 2014)

IL-6 Marker of Liver Failure

IL-6 has long been recognized as an important proinflammatory cytokine whose expression is associated with many inflammatory disorders. Serum levels of IL-6 increase rapidly after infection or organ inflammation and are therefore used in clinical practice as a diagnostic marker to detect inflammatory conditions. levels of IL-6 are also strongly elevated in patients with acute and chronic liver diseases.

IL-6 plays an important role in liver regeneration and protection against liver damage. In addition to IL-6 classic signaling via membrane-bound receptor (mIL-6R), IL-6 signaling can also be mediated by soluble IL-6R (sIL-6R) thereby activating cells that do not express membrane-bound IL-6R.

The role of IL-6 dependent signaling in the liver was mainly attributed to induction of the acute phase response. The functional relevance of IL-6 dependent signaling for regulation of different physiological and pathophysiological conditions in the liver was confirmed in other animal models.

In patients with fulminant hepatic failure or chronic liver diseases, IL-6 expression in serum and liver tissue correlates with disease progression. In contrast to its pathogenic role in liver cancer, IL-6 has been associated with protective functions during hepatic fibrogenesis.

IVD Antibody Development Services for IL-6 Marker

In recent years, IVD technologies are undergoing rapid development. IVD antibodies have been widely used in the diagnosis of numerous diseases. Antibody-based immunoassays are the most generally used diagnostic assays for the detection of biomolecules. With advanced technology and professional scientists, Creative Biolabs is capable of offering a full range of IVD antibody development services against various markers for global customers. In addition, Creative Biolabs provides one-stop diagnostic immunoassay development services, including feasibility analysis, assay design, assay protocol establishment, validation, and production.

For more information, please feel free to contact us and get a quote.

Reference

  1. Hammerich, L., (2014). “Interleukins in chronic liver disease: lessons learned from experimental mouse models.” Clin Exp Gastroenterol 7: 297-306.


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