Introduction of GABBR2
The GABBR2a receptor is one of the GABBR2, and GABBR2 is a G protein-coupled receptor subunit encoded by the GABBR2 gene in humans and regulates the GABBR of inhibitory neurotransmitters through G protein coupling. The metabolism of receptors, widely found in the central nervous system and peripheral tissues, plays an important role in many physiological processes. The structure of GABBR2 is similar to that of GABBR1, especially with 35% homology and 54% similarity at the N-terminus. Both interact with other molecules through the super-helix structure of the C-end. The relative amount of GABBR2 is 110 KDa and there are also 7 transmembrane regions. At present, among the human genes, three sheared isoforms of GABBR2 have been identified: GABBR2a, GABBR2b, and GABBR2c. The difference lies mainly in the structure of the C-terminus. However, its sheared isomers do not affect the formation of heterodimers between GABBR2 and GABBR1.
|Basic Information of GABBR2|
|Protein Name||Gamma-aminobutyric acid type B receptor subunit 2|
|Aliases||GPR51, GPRC3B, HG20, HRIHFB2099, EIEE59, NDPLHS, gamma-aminobutyric acid type B receptor subunit 2|
|Organism||Homo sapiens (Human)|
Function of GABBR2 Membrane Protein
GABBR2 has three effects on GABBR1:
The latest research shows that CGP7930 can bind to GABBR2 and activates GABBR2. CGP7930 becomes the first agonist of GABBR2. Therefore, it is speculated that GABBR2 alone can also constitute a functional receptor. GABBR2 mediates the coupling of G proteins, ligand binding leads to conformational changes, guanine nucleotide binding to G proteins triggers signaling and regulates the activity of downstream effectors. The signal inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium channels and regulates inositol phospholipid hydrolysis.
Fig.1 Structure of GABBR2 membrane protein.
Application of GABBR2 Membrane Protein in Literature
This article reports that they identify a recurring de novo variant in GABAB receptor R2 (GABBR2) that reduces the receptor function, whereas different GABBR2 variants in EE patients possess a more profound effect in reducing receptor activity and are more responsive to agonist rescue in an animal model.
This article reveals that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma.
The article reveals a correlation between GABBR2, GABRA2, and DRD2 variants and cortical spinal cord excitability and cortical inhibition and the age of onset in HD as measured by TMS.
This article shows that the extracellular domain of GBR2 adopts a constitutive open conformation, indicating that the structural asymmetry in the active state of the GABA(B) receptor is unique to the GABAergic system.
This article evaluates that "lose control of ethanol uptake" have different levels of Gabbr1 and Gabbr2 transcription that express the GABA (B1) and GABA (B2) subunits, respectively, in brain regions associated with addictive behavior.
GABBR2 Preparation Options
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