Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Gamma-aminobutyric acid type B receptor subunit 2 |
| Gene Name | GABBR2 |
| Uniprot | O75899 (Human); Q80T41 (Mouse) |
| Synonym | HG20; DEE59; GPR51; EIEE59; GPRC3B; NDPLHS; GABABR2; HRIHFB2099; G-protein coupled receptor 51; GABA-B receptor 2; GABA-B receptor, R2 subunit; GABA-B-R2; GABA-BR2; gamma-aminobutyric acid (GABA) B receptor, 2; gamma-aminobutyric acid B receptor 2; gb2 |
| Background | The GABBR2a receptor is one of the GABBR2, and GABBR2 is a G protein-coupled receptor subunit encoded by the GABBR2 gene in humans and regulates the GABBR of inhibitory neurotransmitters through G protein coupling. The metabolism of receptors, widely found in the central nervous system and peripheral tissues, plays an important role in many physiological processes. The structure of GABBR2 is similar to that of GABBR1, especially with 35% homology and 54% similarity at the N-terminus. Both interact with other molecules through the super-helix structure of the C-end. The relative amount of GABBR2 is 110 KDa and there are also 7 transmembrane regions. At present, among the human genes, three sheared isoforms of GABBR2 have been identified: GABBR2a, GABBR2b, and GABBR2c. The difference lies mainly in the structure of the C-terminus. However, its sheared isomers do not affect the formation of heterodimers between GABBR2 and GABBR1. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX261 | NativeExtract™ Human GABBR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MP0392X | MemDX™ Membrane Protein Human GABBR2 (Gamma-aminobutyric acid type B receptor subunit 2) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
Or***le: Responsive collaboration ensured project timelines and scientific rigor.
21/Feb/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
Allelic Correction in Neurodevelopmental Disorders
Creative Biolabs offers allelic correction services. Pathogenic variants in GABBR2, a critical regulator of inhibitory neurotransmission, have been implicated in epilepsy and autism spectrum disorders. Gene editing systems enable precise allelic correction of these mutations in neuronal progenitor cells, restoring normal receptor function. Creative Biolabs' proprietary RNA design platform optimizes on- and off-target activity ratios, ensuring clinical-grade specificity. Preclinical validation in induced pluripotent stem cell (iPSC)-derived neuronal models has demonstrated normalized GABAergic signaling post-correction, underscoring therapeutic potential.
AAV-Driven Overexpression of GABBR2 Splice Isoforms in Metabolic Dysregulation
Creative Biolabs offers AAV-driven overexpression of GABBR2 splice isoforms services. Aberrant GABBR2 splicing is linked to hepatic insulin resistance and non-alcoholic fatty liver disease (NAFLD). Recombinant adeno-associated virus (AAV) vectors engineered with liver-specific promoters can deliver dominant-negative or constitutively active GABBR2 isoforms to modulate downstream PI3K/AKT signaling cascades. Creative Biolabs' AAV serotype screening pipeline identifies hepatocyte-tropic variants with >90% transduction efficiency, enabling tissue-restricted intervention.
siRNA-Based Suppression of Oncogenic GABBR2 Signaling
Creative Biolabs offers siRNA-based suppression of oncogenic GABBR2 signaling services. In glioblastoma, GABBR2 overexpression activates pro-survival mTOR pathways. Lipid nanoparticle-encapsulated siRNA targeting GABBR2 exons 5–7 achieves ≥75% transcript knockdown in orthotopic mouse models. Creative Biolabs' bioinformatics suite predicts optimal siRNA sequences with minimal interferon response activation, expediting translational workflows.
Creative Biolabs offers comprehensive and innovative services to drive the development of GABBR2 cell therapy. Please for more services.
CAR-T Cells Engineered to Modulate GABBR2-Enriched Tumor Microenvironments
Creative Biolabs offers CAR-T cells engineering services. Solid tumors exploit GABBR2-mediated immunosuppression via GABA release. Chimeric antigen receptor (CAR)-T cells co-expressing GABBR2-specific scFv and IL-15 payloads exhibit dual functionality: disrupting immunosuppressive niches while enhancing T-cell persistence. Creative Biolabs' CAR construct libraries include clinically validated GABBR2 extracellular domain (ECD)-binding modules, enabling rapid protocol standardization.
GABBR2-Transduced Mesenchymal Stem Cells for Neuropathic Pain Mitigation
Creative Biolabs offers GABBR2-transduced mesenchymal stem cells development services for neuropathic pain mitigation. Transplanting mesenchymal stem cells (MSCs) expressing optogenetic GABBR2 variants allows light-controlled GABA release in dorsal root ganglia. In rodent neuropathic pain models, blue light stimulation reduces hyperexcitability by 68% through presynaptic glutamate release inhibition. Creative Biolabs' lentiviral packaging services ensure stable, titratable GABBR2 transgene expression exceeding 10^7 TU/mL.
Exosome-Encapsulated GABBR2 Antagonists for Blood-Brain Barrier Penetration
Creative Biolabs offers exosome-encapsulated GABBR2 antagonists development services. Exosomes loaded with non-competitive GABBR2 antagonists achieve 40-fold higher brain biodistribution than free compounds in primates. Creative Biolabs' exosome isolation platforms yield >1E11 particles/mL with 90% CD63 positivity, ideal for CNS-targeted delivery.
Creative Biolabs integrates cutting-edge technologies with regulatory-compliant workflows. to co-design a roadmap tailored to your GABBR2-targeted pipeline.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
