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GPR153 Membrane Protein Introduction

Introduction of GPR153

GPR153 was originally identified using a hidden Markov model based search approach and was found to be a member of the Rhodopsin family. And then, phylogenetic analyses placed GPR153 in the α-group. The α-group is the only group of GPCRs that has many receptors for biogenic amines which are major drug targets. GPR153 is encoded by the GPR153 gene, which is located at 1p36.31. GPR153 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, frog, and zebrafish. The mass of GPR153 is 65,361 Da.

Basic Information of GPR153
Protein Name Probable G-protein coupled receptor 153
Gene Name GPR153
Aliases G-protein coupled receptor PGR1
Organism Homo sapiens (Human)
UniProt ID Q6NV75
Transmembrane Times 7
Length (aa) 609
Sequence MSDERRLPGSAVGWLVCGGLSLLANAWGILSVGAKQKKWKPLEFLLCTLAATHMLNVAVPIATYSVVQLRRQRPDFEWNEGLCKVFVSTFYTLTLATCFSVTSLSYHRMWMVCWPVNYRLSNAKKQAVHTVMGIWMVSFILSALPAVGWHDTSERFYTHGCRFIVAEIGLGFGVCFLLLVGGSVAMGVICTAIALFQTLAVQVGRQADRRAFTVPTIVVEDAQGKRRSSIDGSEPAKTSLQTTGLVTTIVFIYDCLMGFPVLVVSFSSLRADASAPWMALCVLWCSVAQALLLPVFLWACDRYRADLKAVREKCMALMANDEESDDETSLEGGISPDLVLERSLDYGYGGDFVALDRMAKYEISALEGGLPQLYPLRPLQEDKMQYLQVPPTRRFSHDDADVWAAVPLPAFLPRWGSGEDLAALAHLVLPAGPERRRASLLAFAEDAPPSRARRRSAESLLSLRPSALDSGPRGARDSPPGSPRRRPGPGPRSASASLLPDAFALTAFECEPQALRRPPGPFPAAPAAPDGADPGEAPTPPSSAQRSPGPRPSAHSHAGSLRPGLSASWGEPGGLRAAGGGGSTSSFLSSPSESSGYATLHSDSLGSAS

Function of GPR153 Membrane Protein

GPR153 is an orphan GPCR of which ligand is unknown until now. It is widely expressed in the brain, and specifically high expression in the thalamus, cerebellum and the arcuate nucleus. A new study reveals that GPR153 can also be found in the anterior pituitary (AP) of heifers, and some GPR153 colocalizes with gonadotropin-releasing hormone (GnRHR) in the plasma membrane of bovine gonadotrophs and that its expression is dependent on reproductive stage. In terms of lineage, GPR162 and GPR153 have a common ancestor that split most probably through a duplication event before the divergence of the teleost and the tetrapods lineage. From the view of function, GPR153 knockdown rats displayed slight reduction in food intake and the elevated plus maze test showed significant reduction in the percentage of time spent in the center square, which reveals a probable role of GPR153 in decision making.

Major cellular events of GPCR signaling and trafficking. Fig.1 Major cellular events of GPCR signaling and trafficking. (Irannejad, 2014)

Application of GPR153 Membrane Protein in Literature

  1. Pandey K., et al. Heifers express G-protein coupled receptor 153 in anterior pituitary gonadotrophs in stage-dependent manner. Animal Science Journal. 2017, 89:93-102. PubMed ID: 28960688

    This article reports that not all GPR153 colocalize with GnRHR in the plasma membrane of gonadotrophs, and its expression changes stage-dependently in the bovine the anterior pituitary.

  2. Sreedharan S., et al. The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. Febs Journal. 2011, 278(24):4881-4894. PubMed ID: 21981325

    This report provides the first detailed characterization of the expression, evolution as well as the primary functional properties of the GPR153 gene.

  3. Gloriam D. and Schioth H.R. Nine new human Rhodopsin family G-protein coupled receptors: Identification, sequence characterisation and evolutionary relationship. BBA - General Subjects. 2005, 1722(3):235-246. PubMed ID: 15777626. PubMed ID: 28639411

    This article reports nine new human Rhodopsin family GPCRs, and their Identification, sequence characterization and evolutionary relationship. One of them is GPR153.

  4. Sreedharan S., et al. GPR162 is expressed in the hypothalamus and is involved in food intake related behaviour. Medical & Health Sciences. 2011.

    In the second part of this study, the authors focus on two GPCRs, GPR153 and GPR162. A phylogenetic analysis found that both GPR153 and GPR162 originated from a common ancestor before the radiation of the mammalian lineage.

GPR153 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GPR153 antibody development services.


As a forward-looking research institute as well as a leading customer service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

Reference

  1. Irannejad R. and Von Z.M. (2014). Gpcr signaling along the endocytic pathway. Current Opinion in Cell Biology. 27(1), 109-116.

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