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HighlightsIntroduction of GPR156
GPR156 is encoded by the GPR156 gene which is located at 3q13.33. The mass of GPR156 is 89,097 Da. It belongs to the G-protein-coupled receptors (GPCRs) which are a large superfamily of cell membrane receptors that are characterized by 7 helical transmembrane domains, together with N-terminal extracellular and C-terminal intracellular domains. The alternative names of GPR156 in the literature are GABABL (GABAB-related G-protein coupled receptor) and PGR28.
| Basic Information of GPR156 | |
| Protein Name | Probable G-protein coupled receptor 156 |
| Gene Name | GPR156 |
| Aliases | G-protein coupled receptor PGR28, GABAB-related G-protein coupled receptor |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q8NFN8 |
| Transmembrane Times | 7 |
| Length (aa) | 814 |
| Sequence | MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSFHTQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECTYDLPEGAAPPASSPNKDVQAVASVHTLAAAQGPSGHLSDFQNDPGMAARDSQCTSGPSSYAQSLEGPGKDSSFSPGKEEKISDSKDFSDHLDSGCSQKPWTEQSLGPERGDQVPMNPSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQEVLQDLGLGPEASLSTAPSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSAPSSVGHRANRTVPGAHSRLHVQNGDSPSLAPQTTDSRVRRPSSRKPSLPSDPQDRPGTLEGSKQSQTEPEGARGSKAAFLRQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVPSGCASLSSQHSYFDTESSSSDEFFCRCHRPYCEICFQSSSDSSDSGTSDTDPEPTGGLASWEKLWARSKPIVNFKDDLKPTLV |
Function of GPR156 Membrane Protein
GPR156 belongs to metabotropic glutamate receptor subfamily which are class C G-protein-coupled receptors that respond to the neurotransmitter glutamate. GPR156 functions as a G-protein coupled GABA receptor which means combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein, promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. Beyond that, GPR156 has significant homology to the GABAB receptor subunits. GPR156 showed a considerable ubiquitous expression both in the CNS and in peripheral tissues. And the level of GPR156 mRNA observed in fetal brain is about 20-fold higher than that in the adult brain, it reveals a potential role for GPR156 in neural development.
Fig.1 Schematic representation of the members of class C GPCRs (Kniazeff, 2011).
Application of GPR156 Membrane Protein in Literature
The disclosure provides nucleic acids, including cDNA, comprising alterations that encode aspartic acid at a position corresponding to position 533 of the human GPR156.
This article firstly identifies GPR156 by a homology-based bioinformatics approach. The authors also studied the structure and function of GPR156.
This article intends to reveal the function of genome wide searches for gene-gene interactions based on population genetic data. And the interaction between GPR156 and DNAI2 explain phenotypic differences in depression/anxiety between children.
Authors in this article use structure insight to uncover a common allosteric site in class C GPCRs, GPR156 is a member of subjects, and they find that GPR156 have a Gly in 5x48 potentially allowing the induced fit of modulators through Trp6x50.
GPR156 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GPR156 antibody development services.
As a forward-looking research institute as well as a leading customer service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
Reference
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