GPR26 Membrane Protein Introduction

Introduction of GPR26

GPR26 is encoded by the GPR26 gene. It belongs to the G-protein-coupled receptor (GPCR) family which is increasingly discovered to be numerous therapies for many diseases. It is a central orphan GPCR whose endogenous ligand remains unclear. As to the amino acid sequence, GPR26 shares about 30% identify with serotonin receptor 5-HT5A and gastrin releasing hormone BB2 receptor, suggesting the possibility in regulating energy homeostasis.

Basic Information of GPR26
Protein Name	G-protein coupled receptor 26
Gene Name	GPR26
Aliases	NA
Organism	Homo sapiens (Human)
UniProt ID	Q8NDV2
Transmembrane Times	7
Length (aa)	337
Sequence	MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALFTLNLTCGNLLCTVVNMPLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVVFPLSYRAKMRLRDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCSRRPDERLRFAVFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWGVLSKCLAYSKAASDPFVYSLLRHQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSE

Function of GPR26 Membrane Protein

GPR26 expresses in ventromedial hypothalamic nucleus and cortex abundantly. Using RNA interference method to knock down the expression of GPR26 in C. elegans results in the elevated body fat storage. Furthermore, the GPR26 deficiency mice show decreased energy expenditure and hyperphagia, which lead to the higher possibility of diet-induced obesity as well as propensity to metabolic complications. Consistent with the phenotype of the GPR26 deficiency mice, the level of phosphorylation of AMPK at ser172 increase significantly in GPR26 deficiency mice. The phosphorylation of AMPK activates the downstream relevant signaling pathway to regulate hyperphagia and onset of obesity. Although the detailed physiological function of GPR26 remains unclear, some studies have revealed the key role of GPR26 in energy homeostasis. Targeting GPR26 with monoclonal antibodies or chemical compounds may offer a new therapy for diet-induced obesity.

Fig.1 Structure of GPR26 membrane protein. (Stevens, 2013)

Application of GPR26 Membrane Protein in Literature

Chen D., et al. Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by Activating AMPK in the Hypothalamus. PLOS ONE. 2012, 7(7): e40764. PubMed ID: 22815809

This article identifies GPR26 can modulate the hypothalamic AMPK activation and has hypothalamic AMPK activation, suggesting that the monoclonal antibodies or chemical compounds targeting GPR26 represent novel treatments for obesity.
Romero-Nava R., et al. Evidence of alterations in the expression of orphan receptors GPR26 and GPR39 due to the etiology of the metabolic syndrome. J. Recept. Signal Transduct. 2017, 37(4):422-429. PubMed ID: 28270014

This article analyzes the expression pattern of GPR26 and GPR39 in different tissues. The expression level of GPR26 decreases in the heart and aorta of metabolic syndrome mice model, suggesting that GPR26 and GPR39 may be involved in the development of the metabolic abnormalities.
Carter A.N., et al. GPR26: A marker for primary glioblastoma? Mol. Cell. Probes. 2008, 22(2):133-137. PubMed ID: 18037267

This article identifies GPR26 to be a suppressor of primary glioblastoma development and targeting GPR26 may offer a new approach for primary glioblastoma treatment.
Mori F., et al. G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases. Neuropathology. 2015, 36(1):50-55. PubMed ID: 26303144

The authors in this article apply the immunohistochemical method to examine the expression pattern of GPR26 in patients’ brain tissue and reveal that GPR26 has a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases.
Zhang L.L., et al. GPR26-deficient mice display increased anxiety- and depression-like behaviors accompanied by reduced phosphorylated cyclic AMP responsive element-binding protein level in central amygdala. Neuroscience. 2011, 196:203-214. PubMed ID: 21924326

This article evaluates the phenotype of GPR26 knockout mice and indicates that GPR26 has an important role in the emotion regulation in mice by mediating the phosphorylation of CREB in the central amygdala.

GPR26 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GPR26 antibody development services.

Creative Biolabs is a world-leading custom service provider as well as a forward-looking research company in the field of membrane protein, we have won good reputation among our worldwide customers for successfully finishing numerous challenging projects related to many functional membrane proteins. Please feel free to contact us for more information if you have any questions or suggestions.

Reference

Stevens R. C., et al. (2013) GPCR Network: a large-scale collaboration on GPCR structure and function. Nature reviews. Drug discovery 12(1):25-34.

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