Close

GPR62 Membrane Protein Introduction

Introduction of GPR62

Probable G-protein coupled receptor 62, also known as G-protein coupled receptor GPCR8 or hGPCR8, is a protein that in humans is encoded by the GPR62 gene. As a member of the G protein-coupled receptors family, GPR62 contains 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. During the past years, the functions and applications of GPR62 have been widely studied.

Basic Information of GPR62
Protein Name Putative G-protein coupled receptor GPR62
Gene Name GPR62
Aliases G-protein coupled receptor GPCR8, hGPCR8, G-protein coupled receptor
KPG_005
Organism Homo sapiens (Human)
UniProt ID Q9BZJ7
Transmembrane Times 7
Length (aa) 368
Sequence MANSTGLNASEVAGSLGLILAAVVEVGALLGNGALLVVVLRTPGLRDALYLAHLCVVDLLAAASIMPLGLLAAPPPGLGRVRLGPAPCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTAVWAAAGLLGALSLLGTPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGGIFVVARRAALRPPRPARGSRLHSDSLDSRLSILPPLRPRLPGGKAALAPALAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYSAFAAHPFLYGLLQRPVRLALGRLSRRALPGPVRACTPQAWHPRALLQCLQRPPEGPAVGPSEAPEQTPELAGGRSPAYQGPPESSLS

Function of GPR62 Membrane Protein

G-protein-coupled receptors (GPCRs) participate in diverse physiological functions and are promising targets for drug discovery. Studies have shown that over 140 orphan GPCRs whose functions remain to be elucidated. As a member of the orphan GPCRs, GPR62 is reported to be expressed in the rat and human brain. It has also found that GPR62 is expressed in male germ cells in mice and its expression increases along with sperm differentiation. Most importantly, studies have shown that expression of increasing amounts of GPR62 could increase cAMP levels suggesting that GPR62 is constitutively active on the Gs/cAMP pathway. What’s more, inositol phosphate (IP1) production will increase in a dose-dependent manner up to 40% in cells expressing HA-GPR62. It indicates that GPR62 is constitutively active on the Gq/IP1 pathway in HEK293T cells.

Cross talk between melatonin receptors and orphan GPCRs. Fig.1 Cross talk between melatonin receptors and orphan GPCRs. (Oishi, 2018)

Application of GPR62 Membrane Protein in Literature

  1. Muroi T., et.al. GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice. Reproduction. 2017, 154(6):755-64. PubMed ID: 28912303

    This article suggests that GPR62 could constitutively activate the cAMP pathway in male germ cells but is dispensable for male fertility, which is probably due to its functional redundancy with GPR61.

  2. Oishi A., et.al. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT 2 receptor reciprocally modulate their signaling functions. Scientific reports. 2017, 7(1):8990. PubMed ID: 28827538

    This article suggests that GPR62 could not bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors.

  3. Martin A.L., et.al. Constitutive activity among orphan class-A G protein-coupled receptors. PloS one. 2015, 10(9):e0138463. PubMed ID: 26384023

    This article aims to evaluate the extent of constitutive activity among orphan class-A G protein-coupled receptors within the cAMP signaling pathway. It suggests that identification of inverse agonists may be a fruitful approach for categorizing these orphan receptors and targeting them for pharmacological intervention.

GPR62 Preparation Options

To provide high-quality and cost-effective membrane protein preparation services to worldwide customers, we have successfully established a powerful Magic™ membrane protein production platform for the production of membrane protein products. We are happy to work with you and accelerate the development of your project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GPR62 antibody development services.


Creative Biolabs is committed to delivering the most satisfactory membrane protein products to meet every client’s specific requirements. With years of experience and professional scientists, we are confident in making your program a success. In addition to GPR62 membrane protein preparation, we also offer other membrane protein products. If you are interested in the service we can provide, please feel free to contact us and get more information.

Reference

  1. Oishi A, et.al. (2018). Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function. InInternational Review of Cell and Molecular Biology. 338: 59-77.

Online Inquiry

Verification code
Click image to refresh the verification code.

CONTACT US

45-1 Ramsey Road, Shirley, NY 11967, USA
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us