Introduction of RXFP2
RXFP2 is closely related to the relaxin receptor, LGR7, and has been recently classified as relaxin family peptide (RXFP) receptor. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. It belongs to the class C G-protein-coupled receptor-rich in leucine repeats. Its structural features are that the extracellular region contains leucine repeat repeats (LRRs), and the N-terminal contains a low-density lipoprotein receptor type A module. It plays an important role in signal transduction.
|Basic Information of RXFP2|
|Protein Name||Relaxin Receptor 2|
|Aliases||GPR106, GREAT, LGR8|
|Organism||Homo sapiens (Human)|
Function of RXFP2
RXFP2 can bind to relaxin-2, relaxin-3 and INSL-3, of which INSL-3 has the highest affinity to RXFP2. The phenotypes of RXFP2 knockout mice and INSL-3 knockout mice both show cryptorchidism. INSL-3 binds to RXFP2 distributed in the gubernaculum and regulates the embryonic period testicles drop. However, INSL-3 is not sufficient to mediate normal testicular decline. Testicular decline also requires androgen to regulate suspensory ligament. In addition to its involvement in regulating testicular decline, the INSL-3-RXFP2 system is also involved in regulating follicular atresia and corpus luteum apoptosis in female animals. INSL-3 knockout female mice exhibited accelerated follicular atresia and premature apoptosis of the corpus luteum.
Fig.1 Structure of RXFP2 membrane protein.
Application of RXFP2 in Literature
This article reports that RXFP2 plays a role in testicular descent in fetal life, which suggests an important function of the RXFP2 in cryptorchidism.
This article reveals that a candidate gene encoding a novel G protein-coupled receptor (Great) with an expression pattern suggesting involvement in testicular descent has been identified.
This article reveals the regulating role of the Insl3 factor on the gubernaculum development during the transabdominal descent of the testis.
Author’s group demonstrate that two orphan heterotrimeric guanine nucleotide binding protein (G protein)-coupled receptors, LGR7 and LGR8, are capable of mediating the action of relaxin through an adenosine 3',5'-monophosphate (cAMP)-dependent pathway distinct from that of the structurally related insulin and insulin-like growth factor family ligand.
RXFP2 Preparation Options
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