Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute carrier family 9A2 (SLC9A2) is also known as sodium-hydrogen antiporter 2 (NHE-2) or sodium/hydrogen exchanger 2. It is encoded by the SLC9A2 gene in humans. It’s biased expressed in stomach, colon and 10 other tissues. It belongs to the solute carrier family 9, and functions as a Na+/H+ antiporter. SLC9A2 is localized to the apical membrane and associated with apical absorption of sodium.
| Basic Information of SLC9A2 | |
| Protein Name | Sodium/hydrogen exchanger 2 |
| Gene Name | SLC9A2 |
| Aliases | NHE2 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9UBY0 |
| Transmembrane Times | 10 |
| Length (aa) | 812 |
| Sequence | MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP |
SLC9A2 is also known as sodium/hydrogen exchanger 2 (NHE2) or sodium-hydrogen antiporter 2, which belongs to proton exchangers and transporters. Sodium-hydrogen exchanger (NHE) protein family mediates the sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and plays an important role in cell pH regulation and cell volume. SLC9A2 is localized to the apical membrane and associated with apical absorption of sodium. As a member of SLC9A family, SLC9A2 might be affected by clinical exposure to NSAIDs just like other family members and this will lead to transport modulation and barrier function. While there are different activities between the isoforms, SLC9A2 activation can increase the migratory velocity of RGM1 cells, but SLC9A1 activation can inhibit migratory velocity; SLC9A2 is necessary for mouse gastric epithelial restitution, while SLC9A1 is not essential. SLC9A2 can mediate butyrate-dependent sodium absorption in dextran sulfate sodium-induced colitis. It’s also regulated at the post-translational level, and regulated by different binding proteins.
Fig.1 Topology of SLC9A family. (Hendus-Altenburger, 2014)
This article indicates that SLC9A2 plays an opposite activity compared with SLC9A1. SLC9A1 can increase the migratory velocity of RGM1 cells, while SLC9A2 inhibits this activity.
This article demonstrates that SLC9A2 can mediate butyrate-dependent sodium absorption in DSS induced colitis. This finding provides insight that SLC9A2 can be as a therapeutic target.
This article shows that NHE isoforms including NHE2 might be affected by clinical exposure to NSAIDs, and this will lead to transport modulation and barrier function.
This article demonstrates that NHE2 expression can be upregulated by PKCδ dependent activation of ERK1/2 in the intestinal epithelial cell line.
This article demonstrates that SLC9A2 is necessary for mouse gastric epithelial restitution, while SLC9A1 is not necessary.
With the superior Magic™ membrane protein production platform, we are able to present target membrane protein in multiple active formats. Our professional senior scientists are committed to providing the most suitable method for our clients and maximize the success of your projects. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC9A2 antibody development services.
Creative Biolabs offers high-quality membrane protein preparation services to facilitate the projects of worldwide customers. With years of extensive experience in the field of membrane protein preparation, we have successfully established an advance Magic™ membrane protein platform which enables us to provide a series of membrane protein preparation services. For more detailed information, please feel free to contact us.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
