Solute carrier family 9A3 (SLC9A3) is also known as sodium/hydrogen exchanger 3 (NHE-3) or sodium-hydrogen antiporter 3. It is encoded by the SLC9A3 gene in humans. SLC9A3 is differently expressed in colon, kidney and 9 other tissues. It belongs to the solute carrier family 9, and functions as a Na+/H+ antiporter. SLC9A3 is shown to be involved in pH homeostasis, and signal transduction. Mutations in SLC9A3 gene may cause congenital secretory sodium diarrhea.
|Basic Information of SLC9A3|
|Protein Name||Sodium/hydrogen exchanger 3|
|Aliases||Na(+)/H(+) exchanger 3, NHE-3, Solute carrier family 9 member 3, NHE3|
|Organism||Homo sapiens (Human)|
SLC9A3 belongs to sodium-hydrogen exchanger (NHE) protein family, which mediates the sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions, and plays an important role in cell pH regulation and cell volume. SLC9A3 is an epithelial brush border sodium/hydrogen exchanger which can expel acids from the cells through an inward sodium ion gradient. Mutations in this gene can cause congenital secretory sodium diarrhea. SLC9A3 is very important for intestinal sodium absorption, and downregulation of SLC9A3 has been identified in infectious diseases and is associated with inflammatory bowel diseases (IBD)-associated diarrhea. The expression of SLC9A3 is regulated by DNA methylation. In addition, SLC9A3 has a critical functional role in dilated intercellular spaces (DIS), and SLC9A3 can be a potential therapeutic target in patients with Eosinophilic Esophagitis (EoE). Furthermore, SLC9A3 is associated with colitis through disruption of the gut microbial ecology.
Fig.1 Cellular models for luminal acidification by NHE3. (Pholpramool, 2011)
This article indicates that SLC9A3 plays a critical role in acrosomal formation during spermiogenesis.
This article identifies a common NHE3 single-nucleotide polymorphism-NHE3-799C, and indicates that it’s enriched in Asian populations, and associated with normal function and sensitivity to regulatory ligands.
This article indicates that mutations in NHE3 can lead to congenital sodium diarrhea.
This article shows that SLC9A3 is downregulated in patients with ulcerative colitis.
This article demonstrates that SLC9A3 can promote acid-base regulation through stimulating H+ secretion and HCO3- reabsorption in freshwater rainbow trout.
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