SLC9A7 Membrane Protein Introduction

Introduction of SLC9A7

Solute carrier family 9A7 (SLC9A7) is also known as sodium/hydrogen exchanger 7 or sodium-hydrogen antiporter 7 (NHE-7). It is encoded by the SLC9A7 gene in humans. SLC9A7 is broadly expressed in the brain, lymph node, and 24 other tissues. The SLC9A7 gene is conserved in Rhesus monkey, chicken, chimpanzee, dog, zebrafish, mouse, cow, zebrafish, and frog. It belongs to the solute carrier family 9, and functions as a Na⁺/H⁺ antiporter. The most well-known function of SLC9A7 is to involve in pH homeostasis, and signal transduction.

Basic Information of SLC9A7
Protein Name	Sodium/hydrogen exchanger 7
Gene Name	SLC9A7
Aliases	Na(+)/H(+) exchanger 7, NHE7
Organism	Homo sapiens (Human)
UniProt ID	Q96T83
Transmembrane Times	12
Length (aa)	725
Sequence	MEPGDAARPGSGRATGAPPPRLLLLPLLLGWGLRVAAAASASSSGAAAEDSSAMEELATEKEAEESHRQDSVSLLTFILLLTLTILTIWLFKHRRVRFLHETGLAMIYGLIVGVILRYGTPATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGLNTHAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVNANVTKFTKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKHVFSPIFIIGAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFALAIRDTASYARQMMFTTTLLIVFFTVWIIGGGTTPMLSWLNIRVGVEEPSEEDQNEHHWQYFRVGVDPDQDPPPNNDSFQVLQGDGPDSARGNRTKQESAWIFRLWYSFDHNYLKPILTHSGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSSHTASTSLEGSRRTKSSSEEVLERDLGMGDQKVSSRGTRLVFPLEDNA

Function of SLC9A7 Membrane Protein

As a member of SLC9A family, SLC9A7 mediates the sodium-ion transport and plays an important role in cell pH regulation and cell volume. SLC9A7 is associated with Nef internalization into M2 macrophages. In addition, SLC9A7 is localized to the Golgi network and is associated with pH homeostasis via endocytic and secretory pathways. Moreover, SLC9A7 has a functional role in the development of breast tumors via promoting cell growth, cell adhesion, and invasion. SLC9A7 is associated with sodium-coupled proton loading mechanism in endocytosis. SLC9A7 plays potential dual roles in intracellular compartments, and also indicates the characteristics of subdomains of cell-surface membranes. Furthermore, the trafficking of SLC9A7 can be regulated by secretory carrier membrane proteins.

Fig.1 Topology of SLC9A7.

Application of SLC9A7 Membrane Protein in Literature

Milosavljevic N., et al. The intracellular Na(+)/H(+) exchanger NHE7 effects a Na(+)-coupled, but not K(+)-coupled proton-loading mechanism in endocytosis. Cell Rep. 2014, 7(3): 689-96. PubMed ID: 24767989

This article indicates that SLC9A7 is associated with sodium-coupled proton loading mechanism in endocytosis.
Onishi I., et al. Organellar (Na+, K+)/H+ exchanger NHE7 regulates cell adhesion, invasion and anchorage-independent growth of breast cancer MDA-MB-231 cells. Oncol Rep. 2012, 27(2): 311-7. PubMed ID: 22076128

This article reveals NHE7’s functions in oncogenic processes. NHE7 can modulate cell adhesion, invasion and anchorage-independent growth of breast cancer.
Fukura N., et al. A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes. J Membr Biol. 2010, 234(3): 149-58. PubMed ID: 20364249

This article indicates that the specific regions of NHE7 are critical for NHE7 localization mechanism in the trans-Golgi network which is different from NHE6.
Kagami T., et al. Identification and biochemical characterization of the SLC9A7 interactome. Mol Membr Biol. 2008, 25(5): 436-47. PubMed ID: 18654930

This article shows that NHE7 plays potential dual roles in intracellular compartments, and also indicates the characteristics of subdomains of cell-surface membranes.
Lin P.J., et al. Caveolins bind to (Na+, K+)/H+ exchanger NHE7 by a novel binding module. Cell Signal. 2007, 19(5): 978-88. PubMed ID: 17207967

This article shows the novel mechanism of caveolins binding to NHE7. The caveolins include caveolae/lipid rafts and non-caveolae/lipid raft which display different dynamics.

SLC9A7 Preparation Options

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