SLC9A9, the full protein name is solute carrier family 9 A9. It is also known as sodium/hydrogen exchanger 9 or sodium-hydrogen antiporter 9 (NHE-9), encoded by the gene SLC9A9. SLC9A9 is ubiquitously expressed in the lymph node, esophagus, and 24 other tissues. It functions as a Na+/H+ antiporter. Especially, SLC9A9 is localized in the late recycling endosomes and involved in cation homeostasis.
|Basic Information of SLC9A9|
|Protein Name||Sodium/hydrogen exchanger 9|
|Aliases||Na(+)/H(+) exchanger 9, NHE9, Nbla00118|
|Organism||Homo sapiens (Human)|
The major function of SLC9A9 is to mediate the sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and plays an important role in cell pH regulation and cell volume. SLC9A9 perfectly modulates pH within the endosomal lumen. It’s localized to the late recycling endosomes and plays a critical role in cation homeostasis. It has been reported that mutations in SLC9A9 gene are related to attention deficit and hyperactivity disorder and autism susceptibility. In addition, SLC9A9 plays a role in glioblastoma cells by microRNA-135a by limiting EGFR trafficking. Also, SLC9A9 is identified as an oncogenic member which can promote tumor progression, and it can be a prognostic indicator and therapeutic target in colorectal cancer. This function is mediated by EGFR signaling. Moreover, SLC9A9 can regulate ion uptake at the blood-brain barrier.
Fig.1 Structural modeling of NHE9 and Nhx1. (Kondapalli, 2013)
This article indicates that SLC9A9 plays a functional role in the proliferation and migration of glioblastoma cells via microRNA-135a.
This article shows that the identified SNPs within NHE9 are associated with intraoperative opioid requirements, and this is meaningful for personalized pain treatment.
This article shows the functions of NHE9 variants which are identified in patients with autism and epilepsy.
This article shows that NHE9 up-regulation promotes tumor progression, and indicates that NHE9 can be a prognostic indicator in colorectal cancer.
This article shows NHE9 plays an important regulatory role in iron mobilization pathway at the blood-brain barrier.
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