TAS2R8 Membrane Protein Introduction

Introduction of TAS2R8

Taste receptor type 2 member 8 (TAS2R8 or T2R8) is also known as Taste receptor family B member 5 (TRB5), which is encoded by TAS2R8 gene. TAS2R8 belongs to bitter taste receptor family, a set of typical G-protein coupled receptors (GPCRs). Similar to other TAS2Rs, TAS2R8 also has a 7-transmembrane structure and conserved short N- and C-terminal domains and the intracellular domains share significant conservation. TAS2R8 gene is mapped to chromosome 12p13.2, and it is organized in clusters and genetically linked to loci that influence bitter perception in mice and humans.

Basic Information of TAS2R8
Protein Name Taste receptor type 2 member 8
Gene Name TAS2R8
Aliases Taste receptor family B member 5, TRB5
Organism Homo sapiens (Human)
UniProt ID Q9NYW2
Transmembrane Times 7
Length (aa) 309

Function of TAS2R8 Membrane Protein

As a member of TAS2R family, TAS2R8 mediates the perception of bitter taste in the vertebrates. The canonical distribution of TAS2R8 is found in taste buds of the tongue, where they initiate bitter taste perception to avoid harmful toxins and noxious substances and thus is critical to animal and human survival. However, numerous evidence has shown that TAS2Rs, including TAS2R60, are widely expressed in several extraoral systems, including the digestive, respiratory, and genitourinary systems, as well as in brain and immune cells, indicating the diverse biological functions. TAS2R8 has been found to be activated by bitter compounds in vitro. In addition, several well-known agonists of specific bitter taste receptors have been tested to exhibit anti-cancer effects. It is reported that cell migration, invasion, and matrix metalloproteinases activity are inhibited when TAS2Rs is over-expressed, indicating the chemotherapeutic potential of TAS2Rs. The polymorphisms of TAS2Rs are closely associated with human disorders.

Mechanisms by which five taste qualities are transduced in taste cells. Fig.1 Mechanisms by which five taste qualities are transduced in taste cells. (Chaudhari, 2010)

Application of TAS2R8 Membrane Protein in Literature

  1. Lee Y.H and Song G.G. Genome-wide pathway analysis in glioma. Neoplasma. 2015. 62(2): 230-8. PubMed ID: 25591588

    This article demonstrates that 6 candidate SNPs, 5 genes (TAS2R8, TAS2R7, DLL1, LBP, and LGALS3), and 9 pathways that may contribute to the susceptibility of glioma are identified by using the ICSN Pathway to analyze glioma GWAS data.

  2. Wang J., et al. Plasma autoantibodies associated with basal-like breast cancers. Cancer Epidemiol Biomarkers Prev. 2015, 24(9): 1332-40. PubMed ID: 26070530

    This article identified 13 AAbs (CTAG1B, CTAG2, TP53, RNF216, PPHLN1, PIP4K2C, ZBTB16, TAS2R8, WBP2NL, DOK2, PSRC1, MN1, TRIM21) that distinguished BLBC from controls with 33% sensitivity and 98% specificity.

  3. Seo Y., et al. Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells. PLoS One. 2017, 12(5): e0176851. PubMed ID: 28467517

    This article demonstrates that TAS2R8 and TAS2R10 are endogenously expressed in NB cancer cells and they play noticeable roles in inhibiting the stemness, migration, and invasion of these cancer cells. The effects of these two TAS2Rs on cancer stemness were identified by examining CSC marker expression, self-renewal potentials, and tumorigenicity.

  4. Meyerhof W., et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chemical Senses. 2010, 35(2): 157-170. PubMed ID: 20022913

    The authors challenge 25 human taste 2 receptors (hTAS2Rs) with 104 natural or synthetic bitter chemicals in a heterologous expression system and find that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs.

  5. Chaudhari N and Roper S.D. The cell biology of taste. The Journal of cell biology. 2010, 190(3): 285-296. PubMed ID: 20022913

    This article reviews the functional classes of taste cells and synapses in the taste bud, their cell biology, and current thinking on how taste information is transmitted to the brain.

TAS2R8 Preparation Options

In order to provide high-quality membrane protein preparation service, we have developed advanced Magic™ membrane protein production platform, which can offer many flexible options, from which you can always find the best match for your particular project. Our experienced scientists are very glad to help you get great success. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-TAS2R8 antibody development services.

With abundant knowledge and experience, Creative Biolabs is dedicated to providing first-class membrane protein production service, to promoting the development of your membrane protein programs. Based on our leading-edge platform, we have successfully produced, purified, stabilized and characterized many challenging membrane proteins. If you are interested in the services, please contact us for more information.


  1. Chaudhari N and Roper S D. (2010). The cell biology of taste. The Journal of cell biology. 190(3), 285-296.

Online Inquiry

Verification code
Click image to refresh the verification code.


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
Europe: Heidenkampsweg 58, 20097 Hamburg, Germany
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Our customer service representatives are available 24 hours a day, 7 days a week. Contact Us