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HighlightsTPCN1 (two-pore calcium channel protein 1) is a human protein encoded by the TPCN1 gene. TPCN1 only has two domains, each containing 6 transmembrane segments compared with other calcium and sodium channels. Belonging to ancient members of the voltage-gated ion channel superfamily, TPCN1 is calcium-permeable ion channel localized in the membranes of endolysosomal calcium stores. It might be a predecessor of the conventional four repeat voltage-gated Ca2+ and Na+ channels. TPCN1 has been found to be permeable to both Ca2+ and monovalent cations and its permeability to protons is the highest.
| Basic Information of SV2C | |
| Protein Name | Two pore calcium channel protein 1 |
| Gene Name | TPCN1 |
| Aliases | Two Pore Segment Channel 1, Voltage-Dependent Calcium Channel Protein TPC1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9ULQ1 |
| Transmembrane Times | 14 |
| Length (aa) | 816 |
| Sequence | MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT |
Both TPCN1 and TPCN2 are ion channels that contribute to nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ release from acidic intracellular endolysosomal stores. Increasing researches reported TPC-mediated intracellular signaling in various pathologies, such as Ebola infection, cancer, Parkinson's disease and so on. TPCs exerted their physiological effects via releasing Ca2+ from acidic organelles in response to cues such as the second messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). The Ca2+-releasing ability of TPC1 depended on the ionic composition of the acidic stores and could be influenced by other regulators affecting TPC1 ion permeation.
Fig.1 Secondary structure of TPCN1.
This article revealed different mechanisms of TPC1 and TPC2 in gating regulation and ion conducting properties. And different properties suggested that TPC1 and TPC2 might play complementary physiological roles as Ca2+-release channels of the endolysosomal system.
This article mainly reviewed TPC1 and TPC2 played a role via mediating Ca2+ changes in the pathological process of some diseases such as Parkinson's disease, non-alcoholic fatty liver disease, Ebola infection, cancer, cardiac dysfunction, and diabetes.
This article assessed the relationship between TCPs and non-tumorigenic and tumorigenic breast cell lines, and the results showed that TPC1 and TPC2 might have regulation of signaling processes in breast cancer cells.
This article reported that overexpression of TPC1 enhanced NAADP-mediated calcium signals, while TPC1-knockdown attenuated the signals. It was indicated that TPC1 was important to NAADP action.
This article discovered that TPC1 was permeable to both Ca2+ and monovalent cations, and its permeability to protons was the highest. Both TPC1 and TPC2 could be stimulated by NAADP, but they differed in ion selectivity and modulation by Ca2+ and pH.
In order to meet every client’s requirements, we have developed advanced Magic™ membrane protein production platform which enables us to provide both reconstitution forms and multiple active formats to obtain functional target proteins. Our professional scientists will work closely with you and help you find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-TPCN1 antibody development services.
Creative Biolabs offers a series of membrane protein preparation services for your research needs. Our experienced scientists will do their best to meet every client’s specific requirements. To get more information, please feel free to contact us and get a quote.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
