Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsVoltage-dependent calcium channel proteins (VDCCs), also named as voltage-gated calcium channel proteins (VGCCs), are a group of calcium ion channels present in many cell types from muscle cells and neurons to endocrine cells and lymphocytes. They are multimeric transmembrane proteins that consist of a main pore-forming or α1 subunit and auxiliary subunits, α2δ, and β subunits. And α1 subunit plays a key role in maintaining the normal channel functions. VDCCs mediate the influx of calcium ions into excitable and nonexcitable cells in response to membrane potential changes. And the influx of calcium ions is involved in the many physiological processes, including synaptic transmission, muscle contraction, and gene expression. Additionally, the dysfunctions of VDCCs may lead to the disorder of calcium homeostasis and induce multiple serious human pathophysiological processes, such as muscle disorders, epilepsy, mood disorders, acute and chronic pain, cardiovascular disease, and cancer.
Here shows part of VDCCs in humans including two pore calcium channel protein 1 (TPCN1) and two pore calcium channel protein 2 (TPCN2). TPCN2 possesses four homologous domains with 6 transmembrane segments (S1 to S6) each. While TPCN1 only has two homologous domains containing segments S1 to S6 each. The two pore calcium channel proteins are found in lysosomes and involved in the mediation of calcium release from lysosomal stores in an NAADP-dependent manner.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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