3D Spheroid with Stromal and Endothelial Cell Tri-Culture Model for Immuno-Oncology Drug Discovery and Development

Stromal and endothelial cells play a crucial role in the tumor microenvironment and have significant implications in immuno-oncology drug development. Creative Biolabs launches the 3D spheroid with stromal and endothelial cells tri-culture model to help you with oncology drug development.

Stromal And Endothelial Cells

Advantages of 3D Spheroid With Stromal And Endothelial Cells Tri-Culture Model

• The inclusion of stromal and endothelial cells in the model allows for a more accurate representation of the tumor microenvironment. Numerous cell types, such as immune cells, fibroblasts, and blood arteries, make up the tumor microenvironment. By incorporating stromal and endothelial cells, the tri-culture model aims to recreate this complex environment, providing a more realistic platform for drug testing.
• Studying drug response in a 3D spheroid model is advantageous compared to traditional 2D cell culture systems. 3D models better mimic the physiological conditions found in vivo, allowing for better prediction of drug efficacy and toxicity. In the case of immuno-oncology drugs, this is particularly important as the tumor microenvironment and its interactions with the immune system play a significant role in drug response.
• The tri-culture aspect of this model ensures the inclusion of stromal and endothelial cell interactions with cancer cells. By incorporating these cell types, the tri-culture model better captures the complexity of the tumor microenvironment and its impact on drug response. This could include investigating the effects of stromal cell-secreted factors on immune cell infiltration and activation, or studying the interactions between cancer cells and endothelial cells during angiogenesis.

Fig.1 Fibroblast and endothelial cell content in triple heterotypic spheroids: effect of total cell number and cell ratio.¹

Applications of 3D Spheroid with Stromal and Endothelial Cells Tri-Culture Model

1. This model provides a more physiologically relevant platform for drug testing by recreating the tumor microenvironment and incorporating stromal and endothelial cells.
2. This model can lead to a better understanding of the interactions between cancer cells and their microenvironment, ultimately aiding in the development of more effective immuno-oncology treatments.
3. This model can result in the identification of novel immune targets or the development of combination therapies that target both cancer cells and the supporting stromal and endothelial cells.
4. This model helps researchers gain insights into the mechanisms underlying immune evasion and tumor progression, leading to the development of more effective and targeted immuno-oncology therapies.

With the top technology platform and experienced scientific team, Creative Biolabs offers a highly specialized 3D spheroid with stromal and endothelial cells tri-culture model and related services to accelerate your research. For more detailed information, please feel free to contact us.

Related Sections:

• Tumor Organoid for Immuno-Oncology Drug Discovery and Development
• 3D Spheroid Model for Immuno-Oncology Drug Discovery and Development