3D Ex Vivo Human Adipose Tissue Model Introduction

Creative Biolabs has launched a state-of-the-art 3D ex vivo human adipose tissue model, a breakthrough tool in the field of adipose tissue disease research, and is committed to promoting scientific progress by offering high-quality services to researchers and clinicians worldwide.

Adipose and Related Diseases

Adipose tissue, commonly known as fat, is a specialized connective tissue that serves as a critical regulator of energy homeostasis and metabolic function in the human body. This complex tissue is composed of adipocytes, or fat cells, and a diverse array of other cell types, including immune cells, preadipocytes, and endothelial cells. The intricate interplay between these cell types is responsible for adipose tissue’s essential roles in metabolic homeostasis, endocrine function, and immune regulation. As such, understanding adipose tissue’s function and its response to disease is of vital importance.

M2 macrophages, DCregs, Tregs, eosinophils, and iNKT cells are significant anti-inflammatory immune cells in adipose tissue, and their abundance is mostly decreased in aging adipose tissue. Fig 1. Significant anti-inflammatory immune cells in adipose tissue.¹

Why Choose 3D Ex Vivo Human Adipose Model?

Adipose tissue. (Urkia, 2022)

Traditional Models for Adipose Study

Current research on adipose tissue relies heavily on animal models or in vitro cell cultures, which often lack the complexity and heterogeneity of the human tissue environment. Animal models also face ethical concerns and may not accurately reflect human biology. In vitro cultures are limited by their inability to reproduce the 3D architecture and cellular interactions that occur in vivo, making them unsuitable for studying complex biological processes and drug development.

3D Ex Vivo Human Adipose Tissue Model

Ex vivo human models have emerged as an exciting tool for studying adipose tissue physiology and disease. Our 3D ex vivo human adipose tissue model offers several advantages over traditional models, including its ability to reproduce the complex cellular and extracellular matrix interactions that occur in vivo, making it an excellent tool for studying the mechanisms of adipose tissue diseases and drug development. Moreover, using human tissue models eliminates ethical concerns and provides more relevant and accurate results for clinical translation. Such model also allows for high-throughput screening of potential drug candidates, reducing the time and cost required for drug development.

3D Ex Vivo Human Adipose Tissue Model

Our Services

Creative Biolabs provides high-quality 3D ex vivo human adipose tissue models for researchers around the world. After strict control and optimized collection procedure, our rigorous, comprehensive review process ensures that our models are ethically sourced and of the highest quality. We also offer consultation services to help researchers design experiments and optimize their use of the models. Our inquiry-supply process is straightforward, and we are always available to answer any questions or concerns that our clients may have. Contact us today to learn more about our best possible solutions.

References

Zhang, Yi-Xiang et al. "Adipose tissue aging is regulated by an altered immune system." Frontiers in immunology. 14 (2023): 1125395. Distributed under Open Access license CC BY 4.0, without modification.
Urkia, Nerea et al. "Enhanced Adipogenic Differentiation of Human Dental Pulp Stem Cells in Enzymatically Decellularized Adipose Tissue Solid Foams." Biology. 11,8 (2023): 1099. Distributed under Open Access license CC BY 4.0, without modification.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Models

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