3D Ex Vivo Human Tonsil Tissue Model Introduction

Creative Biolabs provides a reliable source of human tonsil tissue collected through ethical donations, which we use to create highly realistic and accurate models for scientific study as well as a breakthrough innovation in the field of medical research.

Tonsil and Related Diseases

Tonsil is a vital component of the immune system, acting as a first line of defense against infection. It is a small, oval-shaped mass of lymphoid tissue located at the back of the throat, near the base of the tongue. Tonsil contains a variety of immune cells that help to detect and destroy invading pathogens, such as bacteria and viruses.

Despite tonsil's important role in the body's defense against infection, it can also be susceptible to a variety of diseases. These may include tonsillitis, a bacterial or viral infection that causes inflammation and swelling of the tonsil, as well as tonsil cancer and other conditions.

Examination of tonsil tissue samples for B95-8 infection through histological methods. Fig 1. Histological analyses of tonsil tissues infected with B95-8.¹

Why Choose 3D Ex Vivo Human Tonsil Tissue Model

FISH analysis of a tonsillar tumor. (Hopken, 2018)

Traditional Models for Tonsil Study

Traditionally, scientists have relied on animal models and in vitro cell cultures to study Tonsil diseases. However, these models have limitations that can hinder their effectiveness in accurately representing the human Tonsil in disease states. Animal models, for example, may not fully reflect the unique anatomy and physiology of the human Tonsil, while in vitro cell cultures may not accurately capture the complex interactions between different types of cells in the Tonsil.

3D Ex Vivo Human Tonsil Tissue Model

By using human tissue collected through ethical donations, we can create models that accurately reflect the unique anatomy and physiology of the human tonsil. Additionally, these ex vivo models offer a more controlled and standardized environment for studying tonsil diseases, which can improve the reliability and reproducibility of research findings.

3D Ex Vivo Human Tonsil Tissue Model

Our Services

Creative Biolabs takes pride in providing a reliable source of high-quality 3D ex vivo human tonsil tissue model for preclinical drug discovery research. Our model features an industry-leading RNA integrity index score, which ensures that they are of the highest quality, suitable for a wide range of research applications, and greatly improve the success of genomics, genetics and proteomics-related research. We are always happy to hear from our clients and welcome any questions or inquiries about our 3D ex vivo human tissue models, which including but not limited to the models listed below. Contact us today to discuss your research needs and discover how we can provide you with the best possible solutions.

References

Gotoh, K.; et al. Replication of epstein-barr virus primary infection in human tonsil tissue explants. PLOSONE. 2011, 10 (6): e25490. Distributed under CC BY 4.0, without modification.
Hopken, M.; et al. Association of the human bocavirus with tonsil squamous cell carcinomas. Frontiers in Microbiolagy. 2018, 10: 2450. Distributed under CC BY 4.0, without modification.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Models

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