3D Ex Vivo Human Atopic Dermatitis Model Introduction

Creative Biolabs proudly provides 3D ex vivo human atopic dermatitis model, the most advanced and reliable tool for studying chronic inflammatory skin disease. As a leading provider of innovative research solutions, we are committed to helping our clients advance their research for atopic dermatitis.

Atopic Dermatitis

Atopic dermatitis, also known as eczema, is a common and chronic inflammatory skin disease that affects up to 20% of children and 3% of adults worldwide. It is characterized by dry, itchy, and red skin patches that can become swollen, oozing, and prone to infections. Atopic dermatitis has a complex pathogenesis, involving genetic predisposition, immunologic, irritation by allergens and environmental factors, which result in epidermal barrier dysfunction, immune dysregulation, and microbial dysbiosis.

Why Choose 3D Ex Vivo Human Atopic Dermatitis Model

Fig 1. Representative gross images of dorsal and ear lesions. (Shin, et al., 2021)

Traditional Atopic Dermatitis Model

Traditional in vitro and in vivo models have been used to study atopic dermatitis, however, these models have significant limitations that impede the translation of the research findings into clinical applications. Cultured keratinocytes lack the complexity of the skin microenvironment. Animal models are not always representative of human skin physiology and may not recapitulate the complex immune responses seen in atopic dermatitis patients. Therefore, there is an urgent need to develop new and effective models that target the pathogenesis and specific molecular pathways involved in atopic dermatitis.

Fig 2. AD of the flexural surfaces of the extremities.(Kapur, et al., 2018)

3D Ex Vivo Human Atopic Dermatitis Model

The 3D ex vivo human atopic dermatitis Model is a novel and advanced research tool that overcomes the limitations of traditional models. This model is based on the human skin biopsies from atopic dermatitis patients, offers a more physiologically relevant alternative that closely links to the human skin environment. By collecting skin samples from patients with atopic dermatitis, the 3D tissue model incorporates key aspects of the disease and allows for the testing of multiple drug candidates simultaneously, which can accelerate the drug development process.

What We Provide

At Creative Biolabs, we offer 3D ex vivo human model of atopic dermatitis for global researchers. In addition to atopic dermatitis model, we also provide 3D ex vivo human psoriasis model. With our 3D ex vivo human skin disease model, you can achieve the highest success rate for your cytokine secretion analysis, gene expression tests, and immunohistochemistry experiments. Our model helps accelerate the drug development process and improve the lives of millions of people affected by this condition. Contact us today to learn more about our services and how we can support your research goals.

References

Shin, N.; et al. Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling. Stem Cell Res Ther. 2021, 12(1): 482. Distributed under Open Access License CC BY 4.0. The original image was modified by keeping 'Df-induction + Pimercrolimus' mouse.
Kapur, S.; et al. Atopic dermatitis. Allergy Asthma Clin Immunol. 2018, 14 (Suppl 2): 52. Distributed under Open Access License CC BY 4.0, without modification.
Engler, D.; et al. Atopic dermatitis.South African Family Practice. 2018, 60(6): 26-33. Distributed under Open Access License CC BY 4.0.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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