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GPCR Preparation as Immunogen

Based on our world-leading Magic™ membrane protein platform, scientists from Creative Biolabs now provide professional GPCR immunogen preparation service.

G protein-coupled receptors (GPCRs) constitute the largest membrane receptor family with over 800 members. Given their high relevance to diverse diseases, GPCRs act as excellent therapeutic targets of over 40% modern drugs, especially therapeutic antibodies. However, one of the major difficulties for anti-GPCR antibody development lies in the appropriate preparation immunogen, due to their complicated structure and low abundance. After years of devotion, scientists in Creative Biolabs have established a full range of methodologies for obtaining native, functional GPCR proteins that can serve as great immunogens in vivo. We provide flexible options, e.g. detergent micelles, nanodiscs, liposomes, polymers, over-expressing cells, lipoparticles, etc. (as listed below), which from you can always find the best fit for your particular target.

Schematic of GPCR as immunogen or antigen.Figure 1 Schematic of GPCR as immunogen or antigen. (Jo M and Jung ST, 2016)


Creative Biolabs is dedicated to tailoring one-stop membrane protein service to support custom programs from immunogen preparation, antibody discovery, to antibody scale-up production and purification. Please feel free to contact us for more details.

Reference

  1. Jo M and Jung S T. (2016). Engineering therapeutic antibodies targeting G-protein-coupled receptors. Experimental & Molecular Medicine, 48, e207.

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