Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsVirus-like particles (VLPs) are artificial protein structures with a similar overall structure to their corresponding native viruses. They resemble viruses with self-assembly properties but lose original infectious ability due to genome modifications. VLPs are symmetrically built from hundreds of coat proteins, which can be genetically engineered to present a regular arrangement of epitope chains on the desired positions of the outer surface. Compared with monomeric or oligomeric protein carriers, VLPs are able to provide not only a higher density of foreign proteins per particle but also support a distinctive three-dimensional conformation, which is especially important for the presentation of conformational epitopes. Currently, VLPs have been recognized as one of the most promising and extensively studied molecular carriers or nanoparticles, for a variety of applications.
One crucial step for successful VLPs production lies in the proper choice of appropriate expression host system. In general, selection of an ideal system depends on many factors, e.g. the specific target, desired quantity, downstream applications, etc. Creative Biolabs has established a broad range of well-established expression platforms, which can meet diverse research and industrial objectives.
| E. coli System | Yeast System | Insect Cell System | Mammalian Cell System | Plant System |
| The most commonly used system for VLP production with low cost, high yield, and rapid turnaround time. | It's capable of post-translational modifications like glycosylation or phosphorylation, and free of endotoxin concerns. | It's another widely employed system for its fast growth, efficient post-translational modifications, and easy scaling-up. | It can both increase the production flexibility and consistency and maximally recover the native eukaryotic PTMs. | It can decrease the risk of introducing human pathogens and are able to perform large scale production at low cost. |
Our team now provides highly purified and stable VLPs containing a great variety of membrane proteins in the form of lipoparticles to satisfy different demands such as ligand binding assays, antibody screening, and immunogen production.
VLPs can serve as a perfect immunogen that can elicit highly potent immune responses in vivo. We have successfully raised many antibody binders using VLP immunization strategy, particularly against viral antigens or membrane antigens. Our VLPs-based vaccine formulation is able to enhance the antigen immunogenicity remarkably by using adjuvant aluminum salts. Moreover, special methods will be employed to reduce preservative and VLPs aggregation.
Our team is able to apply VLPs as delivery systems to transport various compounds including DNA, siRNA, peptide, protein, and drugs.
Our team is professional in providing VLPs chemical modification services such as probe conjugation for bioimaging application both in vivo and in vitro in virtue of VLPs' high biological compatibility.
We can develop sophisticated VLPs to enable highly specific cell targeting. Alternative approaches are available including vitamins, peptides, nucleic acids (aptamers), and carbohydrates proteins (mainly antibodies).
Creative Biolabs now offers state-of-the-art virus-like particles (VLPs) service and products based on our unparalleled technology platform. Our R&D team is made up of a group of self-inspired and experienced scientists, who are constantly devoted to providing the most professional and satisfactory assistance to our global customers. Please feel free to inquire us for further discussions.
Coxsackievirus A16 (CA16) Virus-Like Particles (VLPs)
Enterovirus 71 (EV71) Virus-Like Particles (VLPs)
Hepatitis B Virus (HBV) Virus-Like Particles (VLPs)
Human Immunodeficiency Virus (HIV) Virus-Like Particles (VLPs)
Human Papillomavirus (HPV) Virus-Like Particles (VLPs)
Poliovirus Virus-Like Particles (VLPs)
MERS-CoV Virus Like Particles (VLPs)
SARS-CoV Virus Like Particles (VLPs)
SARS-CoV-2 Virus Like Particles (VLPs)
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
