ABCC11 Membrane Protein Introduction

Introduction of ABCC11

ABCC11 encoded by ABCC11 gene, also known as MRP8, is a member of the superfamily of ATP-binding cassette (ABC) transporters which transport various molecules across extra- and intracellular membranes. There are seven subfamilies in ABC superfamily named as ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White, respectively. ABCC11 protein belongs to MRP subfamily. It has 1382 amino acids with two membrane-spanning domains that contain 12 transmembrane helixes, and two nucleotide binding domains.

Function of ABCC11 Membrane Protein

ABCC11 has been shown the capacity to transport a broad of lipophilic anions including the natural and synthetic glutathione conjugates LTC4 and dinitrophenyl-S-glutathione (DNP-SG), the steroid sulfates dehydroepiandrosterone (DHEAS) and estrone 3-sulfate (E13S), E217βG, the monoanionic bile acids glycocholate and taurocholate, folic acid, and the folic acid analog methotrexate. Moreover, ABCC11 plays a very important role in multi-drug resistance. ABCC11 has been shown to be responsible for resistance to Zalcitabine, 5-fluorouracil (5-FU), anti-AIDS drugs, and multiple anti-cancer drugs. Recently, most studies pay attention to investigating the expression of ABCC11 in many tumor cells and clarifying the potential role of MRP8 in the chemosensitivity of these cancers. MRP8 has been revealed to be expressed in breast, lung, colon, prostate, ovary, and pancreas tumor cell lines. In addition, some studies showed that an SNP (538G＞A) MRP8 is responsible for determination of human earwax type and presence of underarm odor. And MRP8 is expressed in axons of the central and peripheral nervous system and involves in the production of DHEAS thereby influencing neuronal excitability.

Fig.1 Schematic illustration of ABCC11 protein structure.

Application of ABCC11 Membrane Protein in Literature

1. Nakagawa H., et al. Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma? Medical Hypotheses. 2018, 114: 19-22. PubMed ID: 29602456
   
   

   The study shows that an SNP 538G > A of ABCC11 gene is associated with earwax morphotypes. Based on the findings of the link between the frequencies of the ABCC11 538G allele and the incidences of cholesteatoma in populations, authors hypothesize a possible association between ABCC11, earwax, and the incidence of cholesteatoma.

2. Lang Z., et al. Study of differential gene expression between invasive multifocal/multicentric and unifocal breast cancer. Journal of Buon. 2018, 23(1): 134-142. PubMed ID: 29552773
   
   

   The study identifies 18 overexpression genes and 22 underexpressed genes in invasive multifocal/multicentric breast cancer (MMBC), of which the ABCC11 expression is significantly increased, while ABCB3 is decreased.

3. Byström S., et al. Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density. Breast Cancer Research. 2018, 20(1): 14. PubMed ID: 29444691
   
   

   The study shows that the association between 20 proteins and absolute area-based breast density (AD). And 11 of these proteins have been previously detected in breast tissue. Among 11 proteins, plasma levels of 4 proteins including ABCC11, TNFRSF10D, F11R and ERRF are positively associated and 7 proteins including SHC1, CFLAR, ACOX2, ITGB6, RASSF1, FANCD2 and IRX5 are negatively associated with AD.

4. Soraas L and Stebbing J. Geographic variation in EGFR, mutation frequency in lung adenocarcinoma may be explained by interethnic genetic variation. Journal of Thoracic Oncology. 2018, 13(3): 454-458. PubMed ID: 29246834
   
   

   The study shows that the frequency of EGFR mutations in lung adenocarcinoma is significantly associated with EDAR polymorphism and ABCC11 polymorphism.

5. Ren Y., et al. A missense variant of the ABCC11 gene is associated with Axillary Osmidrosis susceptibility and clinical phenotypes in the Chinese Han Population. Scientific Reports. 2017, 7: 46335. PubMed ID: 28485377
   
   

   The study indicates that an SNP rs17822931 of ABCC11 gene is linked to Axillary osmidrosis (AO) in Chinese Han population. rs17822931-G can significantly increase the risk for AO.

ABCC11 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-ABCC11 antibody development services.

• Magic™ Membrane Protein Production Platform
• Magic™ Anti-Membrane Protein Antibody Discovery Platform

As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.