Introduction of ABCC11
ABCC11 encoded by ABCC11 gene, also known as MRP8, is a member of the superfamily of ATP-binding cassette (ABC) transporters which transport various molecules across extra- and intracellular membranes. There are seven subfamilies in ABC superfamily named as ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White, respectively. ABCC11 protein belongs to MRP subfamily. It has 1382 amino acids with two membrane-spanning domains that contain 12 transmembrane helixes, and two nucleotide binding domains.
|Basic Information of ABCC11|
|Protein Name||ATP-binding cassette sub-family C member 11|
|Organism||Homo sapiens (Human)|
Function of ABCC11 Membrane Protein
ABCC11 has been shown the capacity to transport a broad of lipophilic anions including the natural and synthetic glutathione conjugates LTC4 and dinitrophenyl-S-glutathione (DNP-SG), the steroid sulfates dehydroepiandrosterone (DHEAS) and estrone 3-sulfate (E13S), E217βG, the monoanionic bile acids glycocholate and taurocholate, folic acid, and the folic acid analog methotrexate. Moreover, ABCC11 plays a very important role in multi-drug resistance. ABCC11 has been shown to be responsible for resistance to Zalcitabine, 5-fluorouracil (5-FU), anti-AIDS drugs, and multiple anti-cancer drugs. Recently, most studies pay attention to investigating the expression of ABCC11 in many tumor cells and clarifying the potential role of MRP8 in the chemosensitivity of these cancers. MRP8 has been revealed to be expressed in breast, lung, colon, prostate, ovary, and pancreas tumor cell lines. In addition, some studies showed that an SNP (538G＞A) MRP8 is responsible for determination of human earwax type and presence of underarm odor. And MRP8 is expressed in axons of the central and peripheral nervous system and involves in the production of DHEAS thereby influencing neuronal excitability.
Fig.1 Schematic illustration of ABCC11 protein structure.
Application of ABCC11 Membrane Protein in Literature
The study shows that an SNP 538G > A of ABCC11 gene is associated with earwax morphotypes. Based on the findings of the link between the frequencies of the ABCC11 538G allele and the incidences of cholesteatoma in populations, authors hypothesize a possible association between ABCC11, earwax, and the incidence of cholesteatoma.
The study identifies 18 overexpression genes and 22 underexpressed genes in invasive multifocal/multicentric breast cancer (MMBC), of which the ABCC11 expression is significantly increased, while ABCB3 is decreased.
The study shows that the association between 20 proteins and absolute area-based breast density (AD). And 11 of these proteins have been previously detected in breast tissue. Among 11 proteins, plasma levels of 4 proteins including ABCC11, TNFRSF10D, F11R and ERRF are positively associated and 7 proteins including SHC1, CFLAR, ACOX2, ITGB6, RASSF1, FANCD2 and IRX5 are negatively associated with AD.
The study shows that the frequency of EGFR mutations in lung adenocarcinoma is significantly associated with EDAR polymorphism and ABCC11 polymorphism.
The study indicates that an SNP rs17822931 of ABCC11 gene is linked to Axillary osmidrosis (AO) in Chinese Han population. rs17822931-G can significantly increase the risk for AO.
ABCC11 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-ABCC11 antibody development services.
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