ATP-Binding Cassette Subfamily C

ATP-binding cassette subfamily C (ABCC) belongs to the large family of ATP-binding cassette (ABC) transporters, which are known to translocate various substrates (e.g., metabolic products, lipids, sterols, and xenobiotic drugs) across membranes. This subfamily contains thirteen members, among which nine belong to multidrug resistance proteins (MRPs) that are implicated in mediating multidrug resistance by actively extruding chemotherapeutic substrates. Besides, some of these receptors play an important role in physiological excretory or regulatory pathways. Clinically, MRPs have been proved to be promising targets in cancer therapy and MRP inhibitors or modulators have been developed recently. The second type of protein that belongs to this family is the sulfonylurea receptors (SURs), which are involved in physiological functions such as insulin secretion, neuronal function, and muscle function. Three forms of SUR are known: SUR1, SUR2A, and SUR2B. These proteins are targets of the sulfonylurea class of antidiabetic drugs that promote insulin release from pancreatic beta cells. Additionally, cystic fibrosis transmembrane conductance regulator (CFTR), the transporter involved in the disease cystic fibrosis, is the third type of ABCC receptor subfamily.

Here, we give an introduction of part of these receptors regarding their structure, distribution, physiological and pharmacological functions, and recent findings. Due to their essential role in different diseases, they remain to be attractive targets to be investigated in the future.

Human ATP-Binding Cassette Sub-Family C Members
ABCC1	ABCC10	ABCC11	ABCC2	ABCC3
ABCC4	ABCC5	ABCC6	ABCC8	ABCC9

Membrane proteins are insoluble in aqueous media due to the hydrophobic nature of protein surfaces, thus amphipathic compounds are necessary for extraction of these macromolecules from the native membrane environments and their maintenance in solution. To support this, Creative Biolabs introduces our powerful Magic™ membrane protein production platform, which offers various membrane mimetic systems for in vitro membrane protein manipulation, to help facilitate your membrane protein studies. We are capable of using both conventional/novel detergents and liposomes, as well as novel amphipathic systems such as amphipathic polymers and nanodiscs, to prepare your target proteins.

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