ATP-binding cassette subfamily C (ABCC) belongs to the large family of ATP-binding cassette (ABC) transporters, which are known to translocate various substrates (e.g., metabolic products, lipids, sterols, and xenobiotic drugs) across membranes. This subfamily contains thirteen members, among which nine belong to multidrug resistance proteins (MRPs) that are implicated in mediating multidrug resistance by actively extruding chemotherapeutic substrates. Besides, some of these receptors play an important role in physiological excretory or regulatory pathways. Clinically, MRPs have been proved to be promising targets in cancer therapy and MRP inhibitors or modulators have been developed recently. The second type of protein that belongs to this family is the sulfonylurea receptors (SURs), which are involved in physiological functions such as insulin secretion, neuronal function, and muscle function. Three forms of SUR are known: SUR1, SUR2A, and SUR2B. These proteins are targets of the sulfonylurea class of antidiabetic drugs that promote insulin release from pancreatic beta cells. Additionally, cystic fibrosis transmembrane conductance regulator (CFTR), the transporter involved in the disease cystic fibrosis, is the third type of ABCC receptor subfamily.
Here, we give an introduction of part of these receptors regarding their structure, distribution, physiological and pharmacological functions, and recent findings. Due to their essential role in different diseases, they remain to be attractive targets to be investigated in the future.
|Human ATP-Binding Cassette Sub-Family C Members|
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