Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor A2 |
| Gene Name | ADGRA2 |
| Uniprot | Q96PE1 (Human); Q91ZV8 (Mouse) |
| Synonym | TEM5; GPR124; KIAA1531; G-protein coupled receptor 124; tumor endothelial marker 5 |
| Background | ADGRA2, also known as adhesion G protein-coupled receptor A2 or tumor endothelial marker 5, is a protein that encoded by the human GPR124 gene. Together with two other members of the GPCR protein family, Adgra1 (Gpr123) and Adgra3 (Gpr125), the three genes form a special group of adhesion G protein-coupled receptors A. It has been reported that the extracellular part of Adgra2 contains a leucine-rich repeat (LRR), an immunoglobulin domain (IG), a hormone receptor domain and a G protein-coupled receptor proteolytic site (GPS). And the intracellular part is characterized by a PDZ binding domain. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX322 | NativeExtract™ Human ADGRA2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| Please for more products or customization | ||||
X***er: Technical support streamlined our project timelines.
19/Aug/2023
K***os: Seamless customization of ADGRA2 extracellular domains, including epitope tags and solubilization modifications. Fast turnaround and comprehensive QC data ensured assay-ready material.
23/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Genome Editing
Creative Biolabs offers genome editing services. Gene editing technology enables site-specific modulation of ADGRA2 expression, offering a transformative approach to address pathologies linked to dysregulated G protein-coupled receptor (GPCR) signaling. For instance, knock-in strategies can introduce gain-of-function mutations to amplify ADGRA2's anti-fibrotic activity in hepatic or pulmonary fibrosis models. Creative Biolabs' proprietary gRNA design algorithms ensure high specificity for ADGRA2 locus targeting, minimizing off-target effects while maximizing therapeutic efficacy.
AAV-Driven ADGRA2 Overexpression
Creative Biolabs offers AAV-driven ADGRA2 overexpression services. AAV vectors engineered with tissue-specific promoters can deliver ADGRA2 cDNA to restore receptor function in ischemic cardiovascular disease models. Preclinical studies demonstrate that AAV-mediated ADGRA2 upregulation enhances endothelial cell migration and angiogenesis, critical for post-infarction tissue repair. Creative Biolabs' expertise in capsid optimization ensures efficient transduction of ADGRA2 in complex vascularized tissues, coupled with rigorous biodistribution profiling to confirm target selectivity.
ASO Targeting of ADGRA2 Splice Variants
Creative Biolabs offers ASO targeting of ADGRA2 splice variants services. ASOs designed to modulate ADGRA2 alternative splicing events can selectively enhance or suppress isoforms implicated in neuroinflammatory disorders. For example, targeting exon-skipping mechanisms may augment the production of truncated ADGRA2 variants with dominant-negative effects, attenuating pro-inflammatory signaling in microglia. Creative Biolabs' in-house screening platforms validate ASO efficacy across diverse cellular models, ensuring clinical translatability.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRA2 cell therapy. Please for more services.
ADGRA2-Engineered CAR-T Cells for Solid Tumors
Creative Biolabs offers ADGRA2-engineered CAR-T cells development services. Chimeric antigen receptor (CAR)-T cells expressing ADGRA2-targeting domains exploit the receptor's tumor-specific overexpression to enhance homing to malignancies. For instance, CAR-T constructs incorporating ADGRA2-binding scFv domains exhibit improved infiltration in desmoplastic tumor microenvironments, particularly in pancreatic adenocarcinoma. Creative Biolabs' lentiviral vector production services enable seamless integration of ADGRA2-targeting CAR modules, validated via in vitro cytotoxicity assays and 3D tumor spheroid models.
ADGRA2-Modified MSCs for Tissue Regeneration
Creative Biolabs offers ADGRA2-modified MSCs development services. MSCs engineered to overexpress ADGRA2 demonstrate enhanced paracrine secretion of angiogenic factors, accelerating wound healing in diabetic ulcer models. Transcriptomic profiling reveals ADGRA2's role in modulating Wnt/β-catenin signaling, a pathway critical for MSC-mediated tissue repair. Creative Biolabs' platforms facilitate stable ADGRA2 upregulation in MSCs, paired with functional assays to quantify therapeutic potency.
ADGRA2-Knockout iPSC-Derived Neurons
Creative Biolabs offers ADGRA2-knockout iPSC-derived neurons development services. Induced pluripotent stem cells (iPSCs) with ADGRA2 knockout provide a robust platform to study its neuroprotective role in Alzheimer's disease. Gene edited iPSC-derived neurons lacking ADGRA2 exhibit accelerated amyloid-β accumulation, validating its potential as a therapeutic target. Creative Biolabs offers end-to-end differentiation protocol optimization to generate ADGRA2-deficient neural lineages, complemented by high-content imaging for phenotypic characterization.
With years of experience in the field of membrane protein preparation, Creative Biolabs has successfully developed a series of advanced platforms. Thus, we can provide high-quality membrane protein preparation service for worldwide customers. Our experienced scientists will do their best to help you find an ideal method for your particular project. For more detailed information, please feel free to .
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
