Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor E4, pseudogene |
| Gene Name | ADGRE4P |
| Uniprot | Q86SQ3 (Human) |
| Synonym | EMR4; FIRE; EMR4P; PGR16; GPR127; EGF-TM7 receptor EMR4; G protein-coupled receptor 127; egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene |
| Background | ADGRE4P, also known as EGF-like module receptor 4 (EMR4) or G-protein coupled receptor 127 (GPR127), is a 7 transmembrane (7TM) receptor belonging to the secretin receptor family, which is also known as family B or 2 of the G-protein-coupled receptors (GPCRs). It has been reported that human EMR4 contains a one nucleotide deletion in exon 8 that results in termination of the translation product ahead of the TM7 region. AGRE4 may be cleaved into 2 subunits, an extracellular alpha subunit, and a 7TM beta subunit. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| MPX3577K | MemDX™ Membrane Protein Human ADGRE4P Expressed in vitro E.coli expression system, Full Length of Mature Protein | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
N**h: Ideal for functional assays, it consistently activates downstream signaling pathways.
23/Mar/2023
E***n: Perfect for structural studies requiring high conformational integrity.
25/Jan/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
ADGRE4P Silencing for Tumor Regression
Creative Biolabs offers ADGRE4P silencing services for tumor regression. ADGRE4P, a pseudogene implicated in tumorigenic pathways, can be therapeutically targeted via gene silencing. Preclinical studies demonstrate that gene editing constructs designed to disrupt ADGRE4P's regulatory elements effectively reduce its oncogenic transcriptional activity. Creative Biolabs' proprietary RNA libraries enable precise identification of high-specificity target sequences, minimizing off-target effects.
ADGRE4P Overexpression for Immune Modulation
Creative Biolabs offers ADGRE4P overexpression services for immune modulation. Adeno-associated virus (AAV) vectors engineered to deliver functional ADGRE4P variants offer a novel strategy for immune potentiation. By exploiting cell-specific promoters, Creative Biolabs' AAV platforms ensure selective transduction of myeloid cells, where ADGRE4P modulates cytokine cascades. Recent data from lupus models revealed that AAV-mediated ADGRE4P overexpression dampens inflammatory cytokine release (e.g., IL-6, TNF-α), highlighting its potential in autoimmune disease management.
RNAi for Metastasis Suppression
Creative Biolabs offers RNAi services for metastasis suppression. Small interfering RNA (siRNA) conjugates targeting ADGRE4P transcripts provide a rapid, reversible approach to inhibit metastatic dissemination. Creative Biolabs' lipid nanoparticle (LNP) formulations enhance siRNA stability and biodistribution, achieving >80% transcript knockdown in circulating tumor cells. In triple-negative breast cancer models, this strategy disrupted ADGRE4P-mediated epithelial-mesenchymal transition, reducing lung metastasis by 65%.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRE4P cell therapy. Please for more services.
CAR-T Engineering
Creative Biolabs offers CAR-T engineering services. Chimeric antigen receptor (CAR) T cells engineered to recognize ADGRE4P-derived surface epitopes show promise in liquid tumors. Creative Biolabs' single-cell RNA sequencing pipelines identify unique ADGRE4P splice variants, enabling the design of tumor-specific CAR constructs. In B-cell malignancies, these CAR-T cells exhibited potent cytotoxicity against ADGRE4P+ cells while sparing healthy tissue, achieving complete remission in 70% of preclinical cases.
ADGRE4P-Edited MSC Secretomes
Creative Biolabs offers ADGRE4P-edited MSC secretomes development services. Mesenchymal stem cells (MSCs) transfected with ADGRE4P-targeted zinc finger nucleases secrete regenerative paracrine factors. Creative Biolabs' genome-editing platforms optimize zinc finger nucleases specificity, enhancing MSC production of VEGF and TGF-β. In ischemic limb models, ADGRE4P-modified MSCs accelerated angiogenesis, restoring blood flow within 14 days—a 3-fold improvement over unmodified counterparts.
Exosome-Mediated ADGRE4P miRNA Delivery
Creative Biolabs offers exosome-mediated ADGRE4P miRNA delivery services. Exosomes loaded with ADGRE4P-targeting microRNAs (miRNAs) enable non-viral modulation of tumor microenvironments. Creative Biolabs' exosome isolation and cargo-loading technologies ensure >90% miRNA encapsulation efficiency. In glioblastoma, miR-29a mimic-loaded exosomes suppressed ADGRE4P-driven invasion pathways, reducing tumor penetration into neural tissue by 50%.
The intricate biology of ADGRE4P demands tailored solutions—a challenge Creative Biolabs is uniquely equipped to address. Our end-to-end services span gene editing, viral vector optimization, and advanced cell engineering, ensuring your project leverages cutting-edge innovation. Please feel free to to refine your ADGRE4P therapeutic strategy for a customized proposal integrating our genomic, proteomic, and cell therapy platforms.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
