Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor G2 |
| Gene Name | ADGRG2 |
| Uniprot | Q8IZP9 (Human); Q8CJ12 (Mouse) |
| Synonym | HE6; EDDM6; GPR64; CBAVDX; TM7LN2; G protein-coupled receptor 64; G protein-coupled receptor, epididymis-specific (seven transmembrane family); epididymal protein 6; human epididymis-specific protein 6 |
| Background | ADGRG2, also known as G-protein coupled receptor 64 (GPR64) or Human epididymis-specific protein 6 (HE6), is a protein encoded by the ADGRG2 gene. It is an orphan receptor characterized by a long N-terminus with that has been suggested to be highly glycosylated. Studies have shown that the N-terminus of ADGRG2 is cleaved at the GPS domain to allow for trafficking to the plasma membrane. And the N-terminus after cleavage is believed to remain non-covalently associated with the 7TM. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX388 | NativeExtract™ Human ADGRG2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| Please for more products or customization | ||||
L**a: Superior batch-to-batch consistency and confirmed bioactivity in cell adhesion assays.
12/Aug/2023
F***a: Precise His-tag placement, optimized solubility. Technical support ensured seamless integration into our signaling platform.
27/Mar/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Allelic Correction for ADGRG2 Dysregulation
Creative Biolabs offers allelic correction for ADGRG2 dysregulation services. Therapeutic correction of pathogenic ADGRG2 variants leverages gene editing systems for site-specific genomic editing. For instance, single-nucleotide polymorphisms (SNPs) associated with aberrant G protein-coupled receptor (GPCR) signaling can be precisely excised and replaced with wild-type sequences via homology-directed repair. Recent preclinical studies in renal carcinoma models demonstrate that allelic correction at the ADGRG2 locus restores physiological cAMP signaling, attenuating tumor proliferation by >60% in xenograft assays. Creative Biolabs’ proprietary RNA design algorithms ensure minimal off-target effects, enabling therapeutic-grade editing efficiency essential for translational pipelines.
AAV-Delivered shRNA Knockdown
Creative Biolabs offers AAV-delivered shRNA knockdown services. Adeno-associated virus (AAV) vectors encoding short hairpin RNA (shRNA) sequences enable tissue-specific silencing of ADGRG2 transcription in overexpression pathologies. For example, AAV9 serotypes engineered with kidney-specific promoters selectively deliver shRNA payloads to proximal tubules, achieving >75% reduction in ADGRG2 mRNA in polycystic kidney disease models. This approach mitigates cystogenesis by normalizing fluid transport pathways—a critical advancement for diseases driven by GPCR hyperactivity. Creative Biolabs’ AAV tropism optimization platform ensures precise delivery to ADGRG2-enriched microenvironments, maximizing therapeutic index while minimizing systemic toxicity.
Epigenetic Modulation
Creative Biolabs offers epigenetic modulation services. Quantitative MSD multiplex assays confirm a 3.8-fold increase in ADGRG2 protein levels post-treatment. Creative Biolabs’ epigenetic editing suites provide end-to-end solutions for modulating ADGRG2 expression landscapes, bridging molecular insights to clinical outcomes.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRG2 cell therapy. Please for more services.
ADGRG2-Specific CAR-T Cells
Creative Biolabs offers ADGRG2-specific CAR-T cells development services. Chimeric antigen receptor (CAR) T cells engineered to recognize ADGRG2 extracellular domains enable precise targeting of GPCR-overexpressing malignancies. In glioblastoma models, ADGRG2-CAR-T cells infiltrate tumor stroma, inducing apoptosis via granzyme B release while sparing adjacent neurons. Flow cytometry data reveal 89% target cell depletion within 72 hours, accompanied by sustained interleukin-2 secretion to amplify antitumor immunity. Creative Biolabs’ CAR construct libraries include ADGRG2-specific scFv clones validated for cross-reactivity minimization, a critical factor for mitigating on-target/off-tumor toxicity.
iPSC-Derived ADGRG2+ Renal Progenitors
Creative Biolabs offers iPSC-derived ADGRG2+ renal progenitors development services. Directed differentiation of iPSCs into ADGRG2-expressing renal progenitors offers regenerative solutions for congenital nephropathies. ADGRG2 activation during nephron progenitor differentiation enhances tubular morphogenesis efficiency by 42%, as quantified via 3D organoid imaging. Transplanted progenitors integrate into damaged murine kidneys, restoring glomerular filtration rates to near-physiological levels. Creative Biolabs’ GLP-grade differentiation protocols and RNA-seq quality control pipelines ensure batch-to-batch consistency for scalable therapeutic manufacturing.
Lentiviral ADGRG2 Knock-in for Adoptive Treg Cell Therapies
Creative Biolabs offers lentiviral ADGRG2 knock-in services. Lentiviral vectors encoding ADGRG2 under FOXP3 promoters enable stable GPCR expression in regulatory T (Treg) cells, enhancing their immunosuppressive activity in autoimmune disorders. In experimental autoimmune encephalomyelitis (EAE) models, ADGRG2+ Tregs exhibit 2.1-fold increased IL-10 secretion, suppressing pathogenic Th17 responses and reducing CNS demyelination by 67%. Creative Biolabs’ lentiviral transduction platforms achieve >90% transgene expression in primary T cells, critical for clinical-grade cell therapy production.
Leverage Creative Biolabs’ decade-long expertise in GPCR-focused cell therapy—from target validation to IND-enabling studies—to accelerate your ADGRG2 program. Please feel free to to schedule a consultation to explore customized vector design, functional assays, and translational scalability solutions.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
