Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adhesion G protein-coupled receptor G6 |
| Gene Name | ADGRG6 |
| Uniprot | Q86SQ4 (Human); Q6F3F9 (Mouse) |
| Synonym | APG1; DREG; VIGR; LCCS9; PR126; GPR126; PS1TP2; G-protein coupled receptor 126; HBV PreS1-transactivated protein 2; developmentally regulated G-protein-coupled receptor; vascular-inducible G protein-coupled receptor |
| Background | ADGRG6, also known as developmentally regulated G-protein-coupled receptor (DREG) or G-protein coupled receptor 126 (GPR126), is a protein encoded by the ADGRG6 gene. As a member of the adhesion G protein-coupled receptor (aGPCR) family, ADGRG6 contains a seven-transmembrane domain and a long N-terminal region rich in functional motifs. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX308 | NativeExtract™ Human ADGRG6 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| Please for more products or customization | ||||
M*a: Optimized expression system delivered monodisperse, stable protein.
03/Oct/2023
A***ia: Fast turnaround with detailed SDS-PAGE/ELISA validation accelerated project milestones.
21/Feb/2024
ADGRG6 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
ADGRG6 Knockout for Oncological Indications
Creative Biolabs offers gene knockout services for oncological indications. Precision genome editing enables functional silencing of ADGRG6, a receptor implicated in tumor angiogenesis and metastatic progression. By designing RNAs complementary to exon regions critical for G protein-coupled signaling, researchers can disrupt oncogenic ADGRG6 splice variants in vitro and in vivo models. For instance, conditional knockout in triple-negative breast cancer xenografts has demonstrated attenuated invasion and reduced VEGF secretion. Creative Biolabs' proprietary RNA design algorithms ensure high specificity, minimizing off-target effects—consult our experts to validate target sequences for your preclinical models.
AAV-Delivered shRNA for Fibrotic Disease Modulation
Creative Biolabs offers AAV-driven shRNA development services for fibrotic disease modulation. AAV serotype 9 vectors engineered to deliver short hairpin RNA (shRNA) against ADGRG6 effectively suppress its overexpression in hepatic stellate cells, a hallmark of fibrosis. Preclinical data reveal that intrahepatic administration reduces collagen deposition by >60% in rodent models of cirrhosis. Customizable tissue-specific promoters further refine transduction efficacy. Creative Biolabs' AAV platform optimizes payload capacity and tropism—explore tailored constructs for your therapeutic pipeline.
ADGRG6 Overexpression in Neuroregeneration
Creative Biolabs offers ADGRG6 overexpression services. Targeted activation of conserved enhancer regions elevates ADGRG6 expression by 8–12-fold, correlating with improved motor function recovery in primates. Creative Biolabs' lentiviral libraries streamline multiplexed screening of regulatory elements—leverage our expertise to identify optimal activation targets.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADGRG6 cell therapy. Please for more services.
CAR-T Engineering Targeting ADGRG6-Positive Solid Tumors
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR) T cells targeting ADGRG6's extracellular domain exhibit potent cytotoxicity against glioblastoma and pancreatic adenocarcinoma lines. Third-generation CAR constructs incorporating 4-1BB co-stimulatory domains enhance persistence, while hypoxia-inducible promoters limit off-tumor activity. In murine models, ADGRG6-directed CAR-Ts reduced tumor burden by 85% without triggering cytokine release syndrome. Creative Biolabs' lentiviral transduction protocols ensure >90% CAR expression—engage with our team to optimize antigen-binding domains.
ADGRG6-Engineered MSCs for Osteoarthritis
Creative Biolabs offers ADGRG6-engineered MSCs development services for osteoarthritis. MSCs transfected with ADGRG6 via mRNA electroporation secrete elevated levels of anti-inflammatory cytokines (e.g., IL-10, TGF-β) in synovial fluid, mitigating cartilage degradation. In equine osteoarthritis trials, intra-articular injection restored joint mobility within 4 weeks. Creative Biolabs' non-viral delivery systems maximize transient expression kinetics.
Macrophage Reprogramming via ADGRG6 Knock-In
Creative Biolabs offers ADGRG6 knock-in services. Knock-in of ADGRG6 chimeric receptors into primary macrophages redirects their polarization toward an M2 reparative phenotype. In pulmonary fibrosis models, these engineered macrophages reduced TGF-β1 secretion by 50% and resolved collagen accumulation. Creative Biolabs' ex vivo editing services achieve >70% knock-in efficiency—partner with us to scale GMP-compliant manufacturing.
Navigating the complexities of ADGRG6-targeted therapies demands cutting-edge tools and strategic partnerships. Creative Biolabs' integrated solutions empower your preclinical and clinical milestones. to accelerate your ADGRG6 program with tailored gene editing, cell engineering, and analytical services. Please feel free to to explore our ADGRG6 development portfolio or schedule a technical consultation.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
