Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Adenosine A3 receptor |
| Gene Name | ADORA3 |
| Uniprot | P0DMS8 (Human); Q61618 (Mouse) |
| Synonym | A3AR; adenosine receptor A3 |
| Background | Adenosine receptor A3 (ADORA3) is a protein that in humans is encoded by the ADORA3 gene. The gene contains 2 exons separated by a single intron of about 2.2 kb. The A3 adenosine receptor is found to be expressed in Chinese hamster ovary cells and the agonist binds to membrane preparations inhibited cAMP accumulation. Pharmacologic characterization with several adenosine receptor agonists and xanthine antagonists showed that the human receptor is more similar to the sheep A3 adenosine receptor than to the rat A3 adenosine receptor. Adenosine released during cardiac ischemia exerts an effective, protective effect in the heart. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX339 | NativeExtract™ Human ADORA3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MP0020X | MemDX™ Membrane Protein Human ADORA3 (Adenosine A3 receptor) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
Z**a: Technical support streamlined our receptor signaling studies.
16/Apr/2023
L**a: Seamless ordering, zero QC issues post-delivery.
19/Dec/2023
ADORA3 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
ADORA3-Targeted Genome Editing
Creative Biolabs offers genome editing services. Precision modulation of ADORA3 expression via gene editing systems represents a transformative approach for addressing pathologies linked to dysregulated purinergic signaling. For instance, allelic correction of gain-of-function ADORA3 mutations associated with chronic inflammatory states, such as psoriasis or colitis, can be achieved through homology-directed repair (HDR) templates designed to restore physiological adenosine receptor activity. Creative Biolabs' proprietary RNA libraries and optimized delivery platforms enhance the specificity and efficiency of such interventions, enabling tailored solutions for both preclinical validation and clinical translation.
Adeno-Associated Virus (AAV)-Mediated ADORA3 Overexpression
Creative Biolabs offers AAV-mediated ADORA3 overexpression services. AAV vectors engineered for cell-type-specific ADORA3 overexpression offer therapeutic potential in hypofunctional receptor contexts, such as neuropathic pain or ischemic preconditioning deficits. Preclinical studies in rodent models demonstrate that intraventricular delivery of AAV9-ADORA3 constructs enhances neuroprotective adenosine signaling, attenuating neuronal apoptosis post-stroke. Creative Biolabs' expertise in designing tropism-modified capsids ensures precise targeting of neuronal or immune cell populations, minimizing off-target effects.
siRNA-Based Suppression of Pathogenic ADORA3 Isoforms
Creative Biolabs offers siRNA-based suppression development services. Silencing hyperactive ADORA3 splice variants through lipid nanoparticle-encapsulated siRNA holds promise in oncological contexts, where adenosine-driven immunosuppression fosters tumor immune evasion. For example, targeting the ADORA3B isoform in glioblastoma models reduces adenosine-mediated T-cell exhaustion, synergizing with checkpoint inhibitors. Creative Biolabs' end-to-end siRNA design pipeline—spanning in silico target validation to in vivo efficacy testing—ensures robust, reproducible knockdown.
Creative Biolabs offers comprehensive and innovative services to drive the development of ADORA3 cell therapy. Please for more services.
ADORA3-Specific CAR-T Cell Engineering for Solid Tumors
Creative Biolabs offers ADORA3-specific CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells engineered to recognize ADORA3-overexpressing tumor stromal cells exemplify a novel strategy to disrupt adenosine-rich tumor microenvironments. Preclinical data in pancreatic adenocarcinoma models reveal that ADORA3-targeted CAR-T cells degrade extracellular adenosine pools, thereby reversing immunosuppression and enhancing CD8+ T-cell infiltration. Creative Biolabs' lentiviral transduction protocols and functional validation assays streamline CAR construct optimization—critical for balancing efficacy and cytokine release profiles.
ADORA3-Edited MSCs for Fibrotic Disorder
Creative Biolabs offers ADORA3-edited MSCs development services. MSCs with attenuated ADORA3 expression demonstrate enhanced anti-fibrotic efficacy in murine models of pulmonary fibrosis. Knockout of ADORA3 in MSCs disrupts pro-fibrotic adenosine-A2AR crosstalk, promoting matrix metalloproteinase secretion and collagen degradation. Creative Biolabs' stem cell editing platforms ensure clinical-grade scalability, while our phenotypic screening assays validate therapeutic potency.
ADORA3 Antagonist-Equipped NK Cells for Inflammatory Diseases
Creative Biolabs offers ADORA3 antagonist-equipped NK cells development services. Natural killer (NK) cells armed with membrane-bound ADORA3 antagonistic peptides exhibit augmented cytotoxicity in rheumatoid arthritis synovia, where adenosine suppresses innate immune activity. Ex vivo priming of NK cells using Creative Biolabs' modular protein conjugation kits enhances target engagement without compromising viability.
The translational success of ADORA3-focused therapies hinges on strategic partnerships with seasoned innovators. Creative Biolabs' multidisciplinary expertise empowers clients to navigate technical complexities and accelerate timelines. to explore how our end-to-end services can de-risk your ADORA3 development pipeline, ensuring clinical and commercial triumph.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
