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Adenosine Receptor Family

Adenosine receptors belong to a class of integral membrane proteins known as G-protein-coupled receptors (GPCRs). Members of this class of proteins have seven membrane-spanning α-helices with an extracellular amino terminus and an intracellular carboxy-terminal tail. Adenosine receptors are receptors for adenosine, which is an endogenous nucleoside modulator that exists ubiquitously and modulates many body functions. The four known subtypes are denoted as A1, A2A, A2B, and A3.

These receptors differ in their affinity for adenosine, in the type of G proteins that they recruit, and in the downstream signaling pathways that are activated in the target cells. These receptors are important mediators of cellular signaling, which play vital roles in protecting tissue and organs from damage. Many pathophysiological conditions are believed to be associated with adenosine and their receptors such as asthma, neurodegenerative disorders, chronic inflammatory diseases, and cancer. As a result, adenosine receptor-selective ligands, including agonists and antagonists, have been developed for the treatment of pain, ischemic conditions, glaucoma, asthma, arthritis, cancer, and other disorders in which inflammation is a feature.

Here we give an introduction of different adenosine receptor subtypes in terms of their properties, functions, and applications. Each of them shows a distinct tissue distribution and has been found to be responsible for specific actions and physiological processes. They have been actively studied for different purposes.

Human Adenosine Receptor Members
ADORA1 ADORA2A ADORA2B ADORA3

Creative Biolabs offers the most comprehensive range of membrane protein preparation services for our clients to study the interactions and structure of the targets, to understand their physiology, and to facilitate the rational of effective drug design. Backed by our powerful Magic™ membrane protein production platform, we can prepare these membrane protein targets in various functional formats, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, etc.

Moreover, we can provide cell lines that stably overexpress your targets of interest. The solubilized membrane proteins can be prepared and adapted to different applications, including Magic™ membrane protein antibody discovery, ligand screening, drug discovery, assays and immunoassays.

Adenosine Receptor Family


Creative Biolabs has years of experience in the membrane protein filed and is expert in producing challenging protein targets to support both basic research and discovery projects of our clients. We pursue to provide products with optimal formats, in high purity, and with maximally preserved structural and functional integrity. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.


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