Introduction of ANO10
ANO10, also known as Anoctamin-10 or Transmembrane member 16K (TMEM16K), is a protein that, in humans, is encoded by the ANO10 gene. TMEM16K (ANO10) belongs to a family of ion channels and phospholipid scramblases. Mutations in ANO10 cause neurological and immunological defects, and abrogated ion transport.
|Basic Information of ANO10|
|Organism||Homo sapiens (Human)|
Function of ANO10 Membrane Protein
ANO10, the full name which is Anoctamin-10, does not exhibit calcium-activated chloride channel (CaCC) activity but can inhibit the activity of ANO1. Belonging to a family of ion channels and phospholipid scramblases, ANO10 mutants can cause neurological and immunological defects, and abrogated ion transport. ANO10 supports migration of macrophages and phagocytosis of spirochetes. The detection of mutations in ANO10 in patients indicates that ANO10 defects cause secondary low CoQ10 and SCAR10 patients may benefit from CoQ10 supplementation.
Fig.1 Schematic representation of ANO10. (Balreira, 2014)
Application of ANO10 Membrane Protein in Literature
This article proposes that mutations in ANO10 cause cellular defects and genetic disorders through deranged local Ca2+ signaling.
This article suggests that executive and attentional disorders are impaired in ANO10 mutation. In addition, epilepsy and porencephalic cysts are also described in our ARCA3 patients, the cyst thus expanding the clinical phenotype of ARCA3 patients due to ANO10 mutation.
This study demonstrates for the first time that ANO10 has a central role in innate immune defense against Borrelia infection.
In this article, the detection of mutations in ANO10 in the patients indicate that ANO10 defects cause secondary low CoQ10 and SCAR10 patients may benefit from CoQ10 supplementation.
This article shows that the mutation in ANO10 can cause autosomal recessive spinocerebellar ataxia.
ANO10 Preparation Options
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