Introduction of ASIC2
ASIC2, also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1), is encoded by ASIC2 gene. It belongs to the ASIC/ENaC superfamily, and is widely distributed within mammalian nervous systems as well as non-neural tissues, such as cancer cells, articular chondrocytes and intervertebral disc cells, where it plays significant pathophysiological roles.
|Basic Information of ASIC2|
|Protein Name||Acid-sensing ion channel 2|
|Aliases||ACCN, ACCN1, BNAC1, MDEG|
|Organism||Homo sapiens (Human)|
Function of ASIC2 Membrane Protein
Acid-sensing ion channel 2 (ASIC2) has two hydrophobic transmembrane domains (TM1 and TM2), short intracellular N-and C- termini, and a large cysteine-rich extracellular loop. ASIC2a and ASIC2b subunits are primarily localized in the central nervous system (CNS). Previous studies suggest that ASIC2a shows low sensitivity to reduced extracellular pH (pH50=4.35) and slow channel inactivation. Moreover, ASIC2b does not form functional ion channels by itself. Recent studies show ASIC2 is related with various diseases, such as, Parkinson's disease, Intervertebral Disc Degeneration as well as Arthritis.
Fig.1 The structure and electrophysiological properties of ASICs. (Zhou, 2015)
Application of ASIC2 Membrane Protein in Literature
This article analyzes the expression level of ASIC2 and identifies the function of ASIC2 on colorectal cancer. The results suggest that ASIC2 can highly express in patients with CRC and activate the calcineurin/NFAT1 pathway to promote CRC cells metastasis.
Authors conduct a genome-wide association study of severe GI among 4077 European American adults to find the association between ASIC2 with severe gingival inflammation (GI). The data show that the genetic variation in ASIC2 is significantly associated with severe gingival inflammation and the association is plaque-independent.
Authors in this group reveal the underlying mechanism of ASIC2 differential subcellular distribution. The data suggest ASIC2a plays an important role in membrane targeting of ASIC2b.
This article analyses the association between ASIC2 and ASIC1 expressions in an ASIC2 deletion C57BL/6 mice model. The data demonstrated that ASIC2 deletion plays an important role in acid-activated current in various brain regions, which should be related with acidosis/ischemia-induced neuronal injury.
Authors in this group examine the expression of ASIC2 in human normal and the intervertebral disc (IVD) in TrkB-deficient mice using a variety of methods, such as quantitative-PCR and Western blot. The results suggest that TrkB-ligands might be involved in the regulation of ASIC2 expression.
ASIC2 Preparation Options
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