Plasma cells reside in the bone marrow and can secrete large amounts of antibodies. As a result, engineered plasma cells produce antibodies that are effective therapies for many immune diseases, including infectious diseases. The plasma cells reside in the bone marrow and secrete large quantities of antibodies. However, the development of plasma cell therapy has been limited by the challenges of in vitro modification, culture, expansion, and differentiation techniques of primary human B cells. Creative Biolabs provides one-stop solution B cell engineering services to make antibodies by defending against EBV invasion.
Creative Biolabs offers precise genome editing techniques to engineer B cells, which can secrete EBV antibodies after expansion and differentiation. Our genome editing techniques can be successfully applied to primary human B cells and will also enable studies into the functional interactions between EBV and its primary host cells.
Fig.1 B cell engineering service for anti-EBV antibody delivery. (Creative Biolabs)
Paper Title: Highly efficient CRISPR-Cas9-mediated gene knockout in primary human B cells for functional genetic studies of Epstein-Barr virus infection
Technology: CRISPR/Cas9-based Genome Editing
Journal: PLoS Pathog
IF: 7.464
Published: 2021
Background: Gene editing is now being applied to immune cells, such as CRISPR-Cas9 technology. However, applications to human primary B cells are minimal and limited to activated B cells.
Results: This paper shows how two model genes, CD46 and CDKN2A, are gene-edited in human B cells. CDKN2A encodes the cell cycle regulator p16INK4a, which is an important target for EBV. The study concluded that EBNA3C controls CDKN2A, demonstrating the only barrier to B cell proliferation in EBV-infected cells.
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B Cell Engineering Service for Anti-COVID-19 Antibody Delivery |
| Creative Biolabs provides the B cell engineering service to manufacture antibodies to defend against the invasion of COVID-19 virus. Please click to know more. | |
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B Cell Engineering Service for Anti-HIV Antibody Delivery |
| Creative Biolabs provides the B cell engineering service to manufacture antibodies to defend against the invasion of HIV virus. Please click to know more. | |
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B Cell Engineering Service for Anti-RSV Antibody Delivery |
| Creative Biolabs provides B cell engineering services by different genome editing methods to manufacture antibodies to defend the invasion of RSV. Please click to know more. | |
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B Cell Engineering Service for Anti-Influenza Virus Antibody Delivery |
| Creative Biolabs provides the B cell engineering service to manufacture antibodies to defend against the invasion of influenza virus. Please click to know more. |
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